Acquired resistance of ER- positive breast cancer to endocrine treatment confers an adaptive sensitivity to TRAIL through post-translational downregulation of c-FLIP.

CONCLUSIONS: These results identify a novel mechanism of acquired vulnerability to an extrinsic cell death stimulus, in endocrine resistant breast cancers, which has both therapeutic and prognostic potential. PMID: 29363524 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research

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AbstractPurposeVulvovaginal atrophy (VVA) is a commonly reported issue among breast cancer patients, and its aetiology is multifactorial. Treatment is difficult in these women, particularly because the use of oestrogens has traditionally been discouraged. Vaginal laser treatment has been reported to improve symptoms. We aimed to assess the impact on symptoms and sexual function of vaginal laser in women with early breast cancer (EBC).MethodsWe performed a single-arm investigator initiated pilot study of female EBC patients with symptomatic VVA. A total of 3 vaginal laser treatments were administered 4  weeks apart. Qu...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Conclusion The elucidation of the function of circRNAs is an emerging field of science with a tremendous potential after previously being dismissed as RNA artifacts. They are ubiquitously expressed and thousands of members have already been identified. This fact only expands their potential to possibly enhance our knowledge to understand the difference between health and disease. Owing to their structure stability and their presence in exosomes circRNAs may also exert their function in an autocrine, paracrine and possible endocrine fashion. In addition, the fact that circRNAs are widely distributed in the cellular compart...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Charlotte Witman, from Birmingham, was diagnosed with inflammatory breast cancer in April this year and began the first of 10 rounds of chemotherapy within weeks.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
In this study, we characterized the role of circ-ITCH in TNBC and found that circ-ITCH was significantly down-regulated in TNBC tissues and cell lines and closely associated with poor prognosis. We therefore constructed the MDA-MB-231 and BT-549 TNBC cell lines stably expressing circ-ITCH by lentiviral vectors to determine its underlying mechanisms in TNBC progression. Most importantly, over-expression of circ-ITCH remarkably inhibited TNBC proliferation, invasion and metastasis both in vitro and in vivo. Mechanistically, we found that circ-ITCH acts as a sponge for miR-214 and miR-17 to increase expression of its ITCH lin...
Source: Neoplasma - Category: Cancer & Oncology Authors: Tags: Neoplasma Source Type: research
​BY MARISEL ​​VAZQUEZ​; ARIEN KASRA; &AHMED RAZIUDDIN, MDA 70-year-old woman with a history of breast cancer and a lumpectomy and lymph node dissection 20 years before presented to the ED because of redness and itching for two weeks covering the entire surface of her skin. Two weeks before that, she went for a Pap smear and was prescribed fluconazole for Candida vulvovaginitis infection. She took one dose of the fluconazole and an hour later became itchy and red and felt as if her entire body were burning.The itching and redness were diffuse and had persisted for two weeks, neither worsening nor ...
Source: The Case Files - Category: Emergency Medicine Tags: Blog Posts Source Type: research
ConclusionsAltogether, we propose that regulation of energy metabolism contributes to 1,25(OH)2D3’s anti-cancer effects and that combining 1,25(OH)2D3 with drugs targeting metabolic networks in tumor cells may lead to synergistic effects.
Source: Cancer and Metabolism - Category: Cancer & Oncology Source Type: research
ConclusionThe breast cancer population demonstrates heavy physical symptom burden with multiple physical problems that are related to overall functioning. Special attention should be given to the physical symptom burden of younger, non‐white, unmarried, and unemployed patients. Future research should investigate the PPL of the DT&PL with other measures of symptom burden.
Source: Psycho-Oncology - Category: Cancer & Oncology Authors: Tags: PAPER Source Type: research
I have no idea why my body has changed so much but it has. And I tend to blame chemo for the changes. Since chemo, I have reactions to tons of things. The list of things I am allergic to has grown immensely. I am even allergic to Benadryl....I will say its been a very long time since I was stung by a bee. That is approximately 1986 when I stepped on a bee that had come in through the wall of our kitchen in an apartment. I remember it as being extremely painful because there is no flab on your toe to absorb the venom. I ended up calling the pharmacist to ask for options.... But I also remember it going away mostly by the ne...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: allergens annoyance reactions Source Type: blogs
CONCLUSIONS: This cross-sectional study showed that women treated for DCIS suffered from pain, sensory disturbances and psychological impairment and had unmet rehabilitation needs. Further research is warranted, specifically addressing rehabilitation after diagnosis and treatment of DCIS. PMID: 28447566 [PubMed - in process]
Source: Acta Oncologica - Category: Cancer & Oncology Authors: Tags: Acta Oncol Source Type: research
It’s unbelievable how positively simple and thoughtful healthcare design can impact patients’ healing process! Here, let me show you the finest examples of brilliantly designed devices and medical environments with great potential to bring positive change into medicine. Napoleon and orthopedic casts Did you know that currently used crutches date back to the era of the civil war? Did you know that Napoleon’s famously controversial victory over the Russians in the Battle of Borodino in 1812 helped a French doctor develop an early version of orthopedic casts? Or that the first modern, “pay” hospi...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Healthcare Design 3d printing crutch future future of hospital gc4 plaster cast prosthetic leg Source Type: blogs
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