Plasmodium falciparum genetic variation of var2csa in the Democratic Republic of the Congo

The Democratic Republic of the Congo (DRC) bears a high burden of malaria, which is exacerbated in pregnant women. The VAR2CSA protein plays a crucial role in pregnancy-associated malaria (PAM), and hence quan...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research

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This study aims to evaluate the effectiveness of social group and social group/provider interventions in increasing the demand (use and/or request) for MRDT among community members with fever or malaria-like illness in Ebonyi state, Nigeria.MethodsA three-arm, parallel, stratified cluster randomized design will be used to evaluate the effect of two interventions compared to control: control involves the usual practice of provision of MRDT services by public primary healthcare providers and patent medicine vendors; social group intervention involves the sensitization/education of social groups about MRDT; social group/provi...
Source: Trials - Category: Research Source Type: clinical trials
Journal of Perinatology, Published online: 07 October 2019; doi:10.1038/s41372-019-0512-9Impact of human immunodeficiency virus, malaria, and tuberculosis on adverse pregnancy outcomes in the United States
Source: Journal of Perinatology - Category: Perinatology & Neonatology Authors: Source Type: research
30 million to be offered free NHS flu jab this winter Related items fromOnMedica Swine flu jab in pregnancy safe for children as well as mothers Routine child vaccination coverage rates fall World ’s first malaria vaccine piloted in Malawi babies Parental confidence in immunisation programme ‘very high’ Easter travellers warned over Europe measles outbreak
Source: OnMedica Latest News - Category: UK Health Source Type: news
ConclusionsCurrent interventions for the prevention of malaria in pregnancy are initiated at the first antenatal visit, usually in the second trimester. In this study, we found that many women are already malaria-infected by their first visit. Malaria infection before 24 weeks gestation was associated with dysregulation of essential regulators of angiogenesis, metabolism, and inflammation and an increased risk of PTB. Preventing malaria earlier in pregnancy may reduce placental dysfunction and thereby improve birth outcomes in malaria-endemic settings.
Source: PLoS Medicine - Category: Internal Medicine Authors: Source Type: research
[Citizen] Mtwara/Lindi -At the eighth month of her pregnancy, Asha Wemba, 37, made the first clinic visit to Ufukweni Dispensary. However, it was well past the recommended time.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
Conclusions: Severe malaria is a highly frequent event in pregnant women, without differences by Plasmodium species. It shows early recognizable dangers signs. Hospital under-reporting was identified in 88% of severe cases as well as a lack of laboratory tests for a more comprehensive diagnosis. A protocol for the clinical diagnosis of pregnant women with malaria is required. PMID: 31529822 [PubMed - in process]
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
Malaria remains one of the most important causes of morbidity and death in sub-Saharan Africa. Along with early diagnosis and treatment of malaria cases and intermittent preventive treatment in pregnancy (IPTp...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
Conclusions for PracticeNational health programs looking to improve maternal and child health with ANC pharmaceuticals need to place greater attention on patient counseling and consistent implementation of administration guidelines. Communication that positions pharmaceuticals as beneficial to mother and child, while presenting understandable information about purpose, dosing and potential side effects can promote uptake of multi-drug regimens and ANC services in general.
Source: Maternal and Child Health Journal - Category: Health Management Source Type: research
gerson S, Mueller I, Menéndez C, Requena P Abstract The immune status of women changes during and after pregnancy, differs between blood compartments at delivery and is affected by environmental factors particularly in tropical areas endemic for multiple infections. We quantified the plasma concentration of a set of thirty-one TH1, TH2, TH17 and regulatory cytokines, pro-inflammatory and anti-inflammatory cytokines and chemokines, and growth factors (altogether biomarkers), in a cohort of 540 pregnant women from five malaria-endemic tropical countries. Samples were collected at recruitment (first antenatal ...
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
Authors: Omer SA, Noureldein AN, Eisa H, Abdelrahim M, Idress HE, Abdelrazig AM, Adam I Abstract The aim of the present study was to investigate the prevalence of submicroscopic infections and to assess its impact on maternal anaemia and low birth weight. A cross-sectional study was carried out with 1149 consented pregnant women who delivered at 3 main hospitals in the Blue Nile State, between January 2012 and December 2015. From a matched maternal peripheral, placental maternal side, and cord blood sample, blood films and dried spots were prepared for microscopic examination and nested polymerase chain reaction (n...
Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research
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