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Immediate breast reconstruction after mastectomy does not delay start of chemotherapy or radiotherapy – but may increase risk of complications and readmission

Having immediate reconstruction following a mastectomy does not delay the start of a patient ’ s adjuvant breast cancer therapy but may increase the likelihood of complications requiring hospital readmission in the first six weeks after surgery, according to new research led by researchers at the University of Bristol and the Royal Liverpool University Hospital presented at the UK Interdisciplinary Breast Cancer Symposium (UKIBCS) in Manchester – hosted by leading charity Breast Cancer Now.
Source: University of Bristol news - Category: Universities & Medical Training Tags: Health, International; Faculty of Health Sciences, Faculty of Health Sciences, Bristol Medical School, Faculty of Health Sciences, Population Health Sciences; Press Release Source Type: news

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Journal of Cardiovascular Disease Research,2018,9,1,1-4.DOI:10.5530/jcdr.2018.1.1Published:March 2018Type:Review ArticleBreast Cancer and the Heart: Burden on the ChestAjit Singh,Hashir Kareem,Tom Devasia,Kanav Khera,Sheetal Chauhan,Yeswanth Rao K,andGanesh PAjit Singh*1, Hashir Kareem1, Tom Devasia1, Kanav Khera2, Sheetal Chauhan3, Yeswanth Rao K3, Ganesh P11Department of Cardiology, Kasturba Medical College and Hospital, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA.2Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, INDIA...
Source: Journal of Cardiovascular Disease Research - Category: Cardiology Authors: Source Type: research
Conclusion: The results of the case study describe the effects of undergoing extensive breast cancer therapy on measures of V˙O2peak for a highly aerobically trained, multisport athlete. In this case, exercise training reversed the decrement in measured V˙O2peak that occurred during cancer therapy.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: Clinical Sciences Source Type: research
We report this case involving the RRP induced by TC together with a review of the literature.
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
WebMD wasn't a research option when Ivy Brown was diagnosed with Hodgkin's lymphoma in 1974, so her mother looked up her 12-year-old daughter's condition the old-fashioned way, in a hardcover medical volume. "It just said 'fatal,'" Brown explained. Having moved the family to London a month earlier, Brown's parents were still trying to liaise with her pediatrician in the U.S. "My father told me recently that he was sleeping with the phone on his stomach because of the time change," she said. "They were as scared as you can be when you have a child who you think you might lose," Brown explained....
Source: Science - The Huffington Post - Category: Science Source Type: news
Authors: Health Quality Ontario Abstract OBJECTIVE: The purpose of this review is to determine the effectiveness of 2 separate modalities, digital mammography (DM) and magnetic resonance imaging (MRI), relative to film mammography (FM), in the screening of women asymptomatic for breast cancer. A third analysis assesses the effectiveness and safety of the combination of MRI plus mammography (MRI plus FM) in screening of women at high risk. An economic analysis was also conducted. RESEARCH QUESTIONS: How does the sensitivity and specificity of DM compare to FM?How does the sensitivity and specificity of MRI compa...
Source: Ontario Health Technology Assessment Series - Category: Journals (General) Tags: Ont Health Technol Assess Ser Source Type: research
We examined the effects of surgery type and adjuvant chemotherapy on change in early-stage breast cancer patients' quality of life (QOL) over time. METHODS: A cohort of 549 patients (33.5 % ductal carcinoma in situ, 66.5 % stages I/IIA) were interviewed a mean 6.1 weeks (Time1), and 6.2 (Time2), 12.3 (Time3), and 24.4 (Time4) months following definitive breast-conserving surgery (BCS) or mastectomy. QOL was measured using the total Functional Assessment of Cancer Therapy-Breast (FACT-B). Adjusting for demographic, psychosocial, and clinical variables, multiple linear regression models estimated the asso...
Source: Ann Oncol - Category: Cancer & Oncology Authors: Tags: Ann Surg Oncol Source Type: research
This study investigated the potential to quantify tumour responses to therapy in patients, using quantitative spectral and textural biomarkers extracted from low-frequency ultrasound data (4-10 MHz). Results demonstrate for the first time in a large cohort of patients the ability to predict clinical responders from non-responders as early as one week after the start of chemotherapy with over 95% sensitivity and 95% specificity.A clinical study was undertaken investigating the efficacy of ultrasound to quantify cell death in tumor responses with cancer treatment. Patients (n = 100) with locally advanced breast cancer receiv...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Clinical Trials Source Type: research
The value of adjuvant radiotherapy in triple‐negative breast cancer (TNBC) is currently debated. We assessed the association between adjuvant radiotherapy and survival in a large cohort of Asian women with TNBC. Women diagnosed with TNBC from 2006 to 2011 in five Asian centers (N = 1,138) were included. Survival between patients receiving mastectomy only, breast‐conserving therapy (BCT, lumpectomy and adjuvant radiotherapy) and mastectomy with radiotherapy were compared, and adjusted for demography, tumor characteristics and chemotherapy types. Median age at diagnosis was 53 years (range: 23–96 year...
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Cancer Therapy Source Type: research
Abstract The value of adjuvant radiotherapy in triple negative breast cancer (TNBC) is currently debated. We assessed the association between adjuvant radiotherapy and survival in a large cohort of Asian women with TNBC. Women diagnosed with TNBC from 2006‐ 2011 in five Asian centers (N=1138) were included. Survival between patients receiving mastectomy only, breast conserving therapy (BCT, lumpectomy and adjuvant radiotherapy), and mastectomy with radiotherapy were compared, and adjusted for demography, tumor characteristics, and chemotherapy types. Median age at diagnosis was 53 years (range: 23‐96 years). Median tum...
Source: International Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Cancer Therapy Source Type: research
Over 90% of breast cancer deaths are due to complications as a consequence of metastasis formation. Much progress has been made in understanding primary breast cancer formation; however, metastatic disease is still largely unexplored, poorly understood and incurable. Clearly, there is an urgent need for novel therapies with efficacious anti-metastatic activity. The different steps of the metastatic cascade are largely regulated by reciprocal interactions between cancer cells and their microenvironment. Accumulating evidence indicates that cells and mediators of the immune system can facilitate metastasis formation. To mech...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Adaptive Immune Cells in the Tumor Microenvironment Source Type: research
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