Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes.

Syndecan-1 controls lung tumorigenesis by regulating microRNAs packaged in exosomes.
Am J Pathol. 2018 Jan 17;:
Authors: Parimon T, Brauer R, Schlesinger SY, Xie T, Jiang D, Ge L, Huang Y, Birkland T, Parks WC, Habiel D, Hogaboam C, Gharib SA, Deng N, Liu Z, Chen P
Abstract
Syndecan-1 is a transmembrane proteoglycan expressed prominently by lung epithelium and has pleiotropic functions such as regulating cell migration, proliferation, and survival. Loss of syndecan-1 expression by lung cancer cells is associated with higher-grade cancers and worse clinical prognosis. We evaluated the effect of syndecan-1 in various cell-based and animal models of lung cancer and found that lung tumorigenesis was moderated by syndecan-1. We also demonstrate that syndecan-1 (or lack thereof) altered the microRNA (miRNA) cargo carried within exosomes exported from lung cancer cells. Analysis of the changes in miRNA expression identified a distinct shift toward augmented pro-cancerous signaling, consistent with the changes found in lung adenocarcinoma. Collectively, our work identifies syndecan-1 as an important factor on lung cancer cells that shapes the tumor microenvironment through alterations in miRNA packaging within exosomes.
PMID: 29355516 [PubMed - as supplied by publisher]

Source: The American Journal of Pathology - January 17, 2018 Category: Pathology Authors: Parimon T, Brauer R, Schlesinger SY, Xie T, Jiang D, Ge L, Huang Y, Birkland T, Parks WC, Habiel D, Hogaboam C, Gharib SA, Deng N, Liu Z, Chen P Tags: Am J Pathol Source Type: research