Regulation of low-density lipoprotein cholesterol by intestinal inflammation and the acute phase response

AbstractSystemic inflammation, induced by disease or experimental intervention, is well established to result in elevated levels of circulating triglycerides, and reduced levels of high-density lipoprotein-cholesterol (HDL-C), in most mammalian species. However, the relationship between inflammation and low-density lipoprotein-cholesterol (LDL-C) concentrations is less clear. Most reports indicate that systemic inflammation, as observed during sepsis or following high dose experimental endotoxaemia, lowers total, and LDL-C in man. However, isolated reports have suggested that certain inflammatory conditions are associated with increased LDL-C. In this review, we summarize the emerging evidence that low-grade inflammation specifically of intestinal origin may be associated with increased serum LDL-C levels. Preliminary insights into potential mechanisms that may mediate these effects, including those connecting inflammation to trans-intestinal cholesterol efflux (TICE), are considered. We conclude that this evidence supports the potential downregulation of major mediators of TICE by inflammatory mediatorsin vitro and during intestinal inflammationin vivo. The TICE-inflammation axis therefore merits further study in terms of its potential to regulate serum LDL-C, and as a readily druggable target for hypercholesterolaemia.
Source: Cardiovascular Research - Category: Cardiology Source Type: research

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Source: University of Bristol news - Category: Universities & Medical Training Tags: Health, Research, International; Faculty of Health Sciences, Faculty of Health Sciences, Bristol Medical School, Institutes, Bristol Population Health Science Institute; Press Release Source Type: news
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: JAMA - Category: General Medicine Source Type: research
This article was corrected online.
Source: JAMA - Category: General Medicine Source Type: research
This article was corrected online.
Source: JAMA - Category: General Medicine Source Type: research
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