Reduced live-birth rates after IVF/ICSI in women with previous unilateral oophorectomy: results of a multicentre cohort study

AbstractSTUDY QUESTIONIs there a reduced live-birth rate (LBR) after IVF/ICSI treatment in women with a previous unilateral oophorectomy (UO)?SUMMARY ANSWERA significantly reduced LBR after IVF/ICSI was found in women with previous UO when compared with women with intact ovaries in this large multicentre cohort, both crudely and after adjustment for age, BMI, fertility centre and calendar period and regardless of whether the analysis was based on transfer of embryos in the fresh cycle only or on cumulative results including transfers using frozen-thawed embryos.WHAT IS KNOWN ALREADYSimilar pregnancy rates after IVF/ICSI have been previously reported in case-control studies and small cohort studies of women with previous UO versus women without ovarian surgery. In all previous studies multiple embryos were transferred. No study has previously evaluated LBR in a large cohort of women with a history of UO.STUDY DESIGN, SIZE, DURATIONThis research was a multicentre cohort study, including five reproductive medicine centres in Sweden: Carl von Linn é Clinic (A), Karolinska University Hospital (B), Uppsala University Hospital (C), Linköping University Hospital (D) and Örebro University Hospital (E). The women underwent IVF/ICSI between January 1999 and November 2015. Single embryo transfer (SET) was performed in approximately 70% of all trea tments, without any significant difference between UO exposed women versus controls (68% versus 71%), respectively (P = 0.32), and a maximu...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research