Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

Mutations in LRRK2 are a common genetic cause of Parkinson ’s disease (PD). LRRK2 interacts with and phosphorylates a subset of Rab proteins including Rab8a, a protein which has been implicated in various centr...

Source: Molecular Neurodegeneration - January 23, 2018 Category: Neurology Authors: Jes ús Madero-Pérez, Elena Fdez, Belén Fernández, Antonio J. Lara Ordóñez, Marian Blanca Ramírez, Patricia Gómez-Suaga, Dieter Waschbüsch, Evy Lobbestael, Veerle Baekelandt, Angus C. Nairn, Javier Ruiz-Martínez, Ana Aiastui, Adolfo López de Mun Tags: Research article Source Type: research