Pharma ’ s (Big) Data Problem

By DAVID SHAYWITZ, MD C.P. Snow, author of “The Two Cultures” Despite (some might say, because of) a raft of new biological methods, pharma R&D has struggled with its EROOM problem, the fact that the cost of successfully developing a new drug, including the cost of failures, has been relentlessly increasing, rather than decreasing, over time (EROOM is Moore spelled backwards, as in Moore’s Law, describing the rapid pace of technology improvement over time). Given the impact of technology in so many other areas, the question many are now asking is whether technology could do its thing in pharma, and make drug development faster, cheaper, and better. Many major pharmas believe the answer has to be yes, and have invested in some version of a by-now familiar data initiative aimed at aggregating and organizing internal data, supplementing this with available public data, and overlaying this with a set of analytical tools that will help the many data scientists these pharmas are urgently hiring to extract insights and accelerate research. A bevy of established companies and consultancies, including Deloitte, Accenture, BCG, and McKinsey, are championing some version of this vision, along with a number of younger companies, including Silicon Valley powerhouse Palantir, and startups like Datavant. Two significant challenges associated with this vision are: (1) How do you achieve it? (2) Will it actually work? These are each enormous unknowns with which the entire i...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Uncategorized CP Snow Culture Data David Shaywitz Source Type: blogs

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Authors: San C, Lê MP, Matheron S, Mourvillier B, Caseris M, Timsit JF, Wolff M, Yazdanpanah Y, Descamps D, Peytavin G Abstract HIV infection has evolved into a chronic disease with comorbidities since the combination antiretroviral therapy era. Complications still occur and patients may need to be admitted to an intensive care unit. Acute respiratory failure is the first cause of these admissions, questioning the administration of solid oral dosage formulations. This issue is also observed in geriatric units where the prevalence of dysphagia is high and underestimated. The problem of antiretroviral administr...
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Authors: Petitdemange A, Martin A, Ruch Y, Chatron E, Karol A, Hansmann Y PMID: 31722863 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Authors: Soumah A, Avettand-Fenoel V, Veber F, Moshous D, Mahlaoui N, Blanche S, Frange P Abstract OBJECTIVES: To assess the outcome of HIV-infected individuals attending one of the largest French pediatric HIV centers in 2016-2017 and to compare the rates of antiretroviral coverage and virological suppression with the UNAIDS targets. PATIENTS AND METHODS: The clinical and immuno-virological status of 163 HIV-1-infected children and adolescents attending Necker Hospital in Paris, France, were investigated. Virological suppression was defined as an HIV-1 viral load
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Authors: Voitey M, Bouiller K, Chirouze C, Fournier D, Bozon F, Klopfenstein T Abstract INTRODUCTION: Little is known about the functional symptoms associated with Lyme borreliosis (LB) in Europe. We aimed to assess functional symptoms associated with presumed LB and to compare patients with and without confirmed LB. MATERIALS AND METHODS: We performed a retrospective monocenter study. Patients consulting for presumed LB were included. RESULTS: Between November 2015 and June 2018, 355patients were included (mean age: 51years, 52% of women) of which 48had LB: erythema migrans (42%), early disseminated LB (50...
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Authors: Rahman M, Beg S PMID: 31722657 [PubMed - in process]
Source: Recent Patents on Anti-Infective Drug Discovery - Category: Infectious Diseases Tags: Recent Pat Antiinfect Drug Discov Source Type: research
Publication date: Available online 15 November 2019Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Konstantinos I. Tosios, Eleni-Marina Kalogirou, Nikolaos G. Nikitakis
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionThe method achieved high performance for automation of tooth segmentation on dental panoramic images. The proposed method might be applied in the first step of diagnosis automation and in forensic identification, which involves similar segmentation tasks.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionsSequestra and periosteal new bone formation were characteristic CT features of osteomyelitis that were found more commonly in the medication-related condition. These findings may be useful in the evaluation of osteomyelitis and medication-related osteonecrosis of the jaw.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
ConclusionAcceptance QA testing was effective in detecting discrepancies and establishing optimal exposure doses that were within the DRL and AD established by the National Council on Radiation Protection and Measurements and the ESE established by the state of Texas.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: Available online 15 November 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): L. May, J. Blatter, P. Bize, G. Tsoumakidou, A. Denys, M. BroomeAbstractTreatment of bony tumours of the oral and maxillofacial area usually involve resection. However, access to certain areas may be difficult because of the size or site of the tumour. A poor view of the lesion during operation is another limiting factor, which can lead to incomplete resection in difficult cases. Percutaneous cryoablation is a common procedure for treating benign and malignant bony lesions outside the oral and maxillofacia...
Source: British Journal of Oral and Maxillofacial Surgery - Category: ENT & OMF Source Type: research
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