Ruthenium dendrimers as carriers for anticancer siRNA.

This article is devoted to study interactions between new carbosilane-based metallodendrimers containing ruthenium and anti-cancer small interfering RNA (siRNA). Formation of complexes between anti-cancer siRNAs and Ru-based carbosilane dendrimers was evaluated by transmission electron microscopy, circular dichroism and fluorescence. The zeta-potential and the size of dendriplexes were determined by dynamic light scattering. The internalization of dendriplexes were estimated using HL-60 cells. Results show that ruthenium dendrimers associated with anticancer siRNA have the ability to deliver siRNA as non-viral vectors into the cancer cells. Moreover, dendrimers can protect siRNA against nuclease degradation. Nevertheless, further research need to be performed to examine the therapeutic potential of ruthenium dendrimers as well as dendrimers complexed with siRNA and anticancer drugs towards cancer cells. PMID: 29353086 [PubMed - as supplied by publisher]
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research

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This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age. Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract High mobility group box 1 (HMGB1), a highly conserved protein, presents in almost all somatic cells and is necessary for transcription regulation during cell development. Recent studies indicate that HMGB1 is important for inflammation, tissue regeneration and cancer, especially the balance between autophagy and apoptosis. HMGB1 shows a challenge that can be used for therapeutic improvement while preventing its pathological role. Here, we pay attention to the immuno-regulatory effect of HMGB1. PMID: 31223085 [PubMed - as supplied by publisher]
Source: Current Gene Therapy - Category: Genetics & Stem Cells Authors: Tags: Curr Gene Ther Source Type: research
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Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Cancer Gene Therapy, Published online: 20 June 2019; doi:10.1038/s41417-019-0113-yA simplified system for the effective expression and delivery of functional mature microRNAs in mammalian cells
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
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Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
Cancer Gene Therapy, Published online: 20 June 2019; doi:10.1038/s41417-019-0116-8Translatable gene therapy for lung cancer using Crispr CAS9—an exploratory review
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
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Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
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Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
Cancer Gene Therapy, Published online: 17 June 2019; doi:10.1038/s41417-019-0110-1Enhanced antitumor efficacy of an oncolytic adenovirus armed with an EGFR-targeted BiTE using menstrual blood-derived mesenchymal stem cells as carriers
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
This study focuses on four PAEM-based polycations with well-defined molecular weight and chain architecture. The polymers include three cyclodextrin (CD)-cored star-shaped PAEM polycations (s-PAEM), synthesized by atom transfer radical polymerization (ATRP), and a linear PAEM polycation (l-PAEM), synthesized via activators regenerated by electron transfer (ARGET) ATRP. All four polycations could condense plasmid DNA (pDNA) into spherical polyplexes with small sizes (
Source: Colloids and Surfaces - Category: Biotechnology Authors: Tags: Colloids Surf B Biointerfaces Source Type: research
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