Repairing the female pelvic floor: when good enough is not good enough

Repairing the female pelvic floor: when good enough is not good enoughRepairing the female pelvic floor: when good enough is not good enough, Published online: 23 January 2018; doi:10.1038/nrurol.2017.219Women commonly experience pelvic floor damage during pregnancy and vaginal childbirth and later develop stress urinary incontinence and prolapse. Polypropylene mesh can repair abdominal hernias, but complications result when used in the female pelvic floor. In October, the Royal Society hosted a workshop to address issues surrounding pelvic floor disorders.
Source: Nature Reviews Urology - Category: Urology & Nephrology Authors: Source Type: research

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The reluctance to operate on pregnant women is not new and is based on limited and flawed data.1 We fear that the conclusions advanced in the recent publication by Fong and colleagues2 may serve as unjustified support for such delay in surgery, exposing pregnant women to complications.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Letter Source Type: research
We thank Tolcher and colleagues for their interest in our study.1 However, we disagree with their position that cholecyststectomy in the third trimester is safe for both the pregnant woman and the baby. In their review article,2 old, uncontrolled, and underpowered studies are quoted to justify their recommendation to proceed with surgery during pregnancy. These same inadequate studies were used to justify current guidelines.3 In comparison, our analysis of nearly 18,000 pregnant women undergoing cholecystectomy in the third trimester or the 90 days after delivery is properly controlled and powered to draw appropriate conclusions.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Letter Source Type: research
Publication date: Available online 16 August 2019Source: European Journal of Obstetrics &Gynecology and Reproductive BiologyAuthor(s): Andrew Sharp, Richard Jackson, Christine Cornforth, Jane Harrold, Mark A. Turner, Louise Kenny, Philip N. Baker, Edward D. Johnstone, Asma Khalil, Peter von Dadelszen, Aris T. Papageorghiou, Zarko AlfirevicAbstractBackgroundSevere early-onset fetal growth restriction (FGR) predisposes to fetal death, neonatal death, neonatal morbidity and neurodisability. The use of placental biomarkers has been proposed for risk stratification in pre-eclampsia, but they could be equally useful in fetal...
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
We examined several parameters including reproductive performance of dams, physical development, postnatal reflex ontogeny, locomotor behavior, neuromuscular strength, anxiety, anhedonic behavior, cognitive abilities and microglia populations in the F1 progeny. The study showed improved reproductive performance of Spirulina supplemented protein malnourished dams, accelerated acquisition of neurological reflexes, better physical appearance, enhanced neuromuscular strength, improved spatial learning and memory and partly normalized PMN induced hyperactivity, anxiolytic and anhedonic behavior in offspring. These beneficial ef...
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Mingshu Xiao, Lihu Gao, Arun Richard Chandrasekaran, Jianfeng Zhao, Qian Tang, Zhibei Qu, Fei Wang, Li Li, Yang Yang, Xueli Zhang, Ying Wan, Hao PeiAbstractDevelopment of biomedical materials for proper collagen deposition is of great importance to accelerate wound healing and thus achieving skin regeneration. Here, we report guanosine quartet hydrogels loaded with recombinant human-source collagen (G4-RHC) that can be used as medical patches for wound repair. The G4-RHC hydrogels are flexible, and when wrapped onto the skin s...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 16 August 2019Source: Seminars in Cell &Developmental BiologyAuthor(s): Dominic Julian, Ethan W. Hollingsworth, Katherine Julian, Jaime ImitolaAbstractHuman central nervous system (CNS) regeneration is considered the holy grail of neuroscience research, and is one of the most pressing and difficult questions in biology and science. Despite more than 20 years of work in the field of neural stem cells (NSCs), the area remains in its infancy as our understanding of the fundamental mechanisms that can be leveraged to improve CNS regeneration in neurological diseases is still growing. Here...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
ConclusionsThis was presumed to be a rare case of twin pregnancy by triploid embryo formation, followed by loss of an allele due to postzygotic diploidization, development of a diploid fetus, and development of another fetus from a separate embryo. Because of the existence of cases such as this one with a diploid fetus, but without a normal pregnancy coexistent with a complete hydatidiform mole, diagnosis by genetic analysis is required for prognosis.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
In this study, we determined the impacts of growth pattern to the end of the mating period and sire genetics on the reproductive performance of Merino ewe lambs. Five hundred ewe lambs with full pedigree records were managed under commercial conditions from weaning and weighed 43.5 kg at the start of the mating period with an average age of 224 days. The ewe lambs were offered a moderate or high feed allowance to achieve target growth rates of 100 or 200 g/day during a 46-day mating period. They were then recombined and scanned for pregnancy status 60 days after the mating period. At the individual animal lev...
Source: Small Ruminant Research - Category: Zoology Source Type: research
Authors: Appak Ö, Manyaslı M, Cengiz MM, Deliloğlu B, Karaoğlu Asrak H, Özlü C, Sayıner AA Abstract The screening for syphilis during pregnancy is important to prevent intrauterine transmission and complications. Prozone phenomenon may cause a false negative result in non-treponemal syphilis tests, which complicates an accurate diagnosis. In this case report a newborn syphilis case was presented to emphasize the importance of reverse algorithm in diagnosis and the prozone phenomenon which can cause problems in rapid plasma reagin (RPR) test. The 2920 g infant patient was born from a 24-year-old m...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Journal Name: Journal of Perinatal Medicine Issue: Ahead of print
Source: Journal of Perinatal Medicine - Category: Perinatology & Neonatology Source Type: research
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