Does spotty calcification attenuate the response of nonculprit plaque to statin therapy?: A serial optical coherence tomography study
Abstract ObjectivesThe aim of this study was to determine if spotty calcification decreases the response of plaque progression to statin therapy. BackgroundPrevious studies showed that the presence of spotty calcification is a marker of vulnerable plaque. However, the relationship between spotty calcification and plaque progression is not clear. MethodsNinety‐six nonculprit lipid‐rich plaques in 69 patients who received serial optical coherence tomography (OCT) imaging were included. Plaques were divided into three groups: spotty calcification (n = 38), calcified (n = 12) and noncalcified (n = 46) plaques. Spotty calcification was identified by the presence of a lesion
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DR MAX PEMBERTON: As a nation we've become enormously reliant on medication to manage our health and we happily reach for statins or blood pressure tablets.
ConclusionsMetformin can limit the development of atherosclerosis secondary to diabetes in young diabetic mice. A possible mechanism is the removal of methylglyoxal, thereby reducing the formation of advanced glycation endproducts, rather than by lowering the blood glucose level.FundingThis work was supported by the National Natural Science Foundation of China (81901106) and Jinan clinical medical science and technology innovation plan (201907002).
In this study, we reviewed in-vitro and in-vivo studies, as well as clinical reports pertaining to the antifungal efficacy of statins. In addition, we have addressed various modulators of statin anti-fungal activity and the potential mechanisms responsible for their anti-fungal effects. In general, statins do possess anti-fungal activity, targeting a broad spectrum of fungal organisms including human opportunistic pathogens such as Candida spp. and Zygomycetes, Dermatophytes, alimentary toxigenic species such as Aspergillus spp., and fungi found in device implants such as Saccharomyces cerevisiae. Statins have been shown t...
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In this study, we developed a high-throughput small molecule screen for YAP inhibitors in primary human lung fibroblasts (HLF). Multiple hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) were found to inhibit YAP nuclear localization via induction of YAP phosphorylation, cytoplasmic retention and degradation. We further show that the mevalonate pathway regulates YAP activation, and that simvastatin treatment reduces fibrosis markers in activated HLF and in the bleomycin mouse model of pulmonary fibrosis. Finally, we show simvastatin modulates YAP in vivo in mouse lung fibroblasts. Our results hi...
Whether you have a stomachache, a wrist sprain or a chronic disease, one of the first things doctors and nurses will do at an appointment is take your temperature. A normal temperature means your body is humming along the way it should. A higher temperature means you have a fever, and shows your body could be fighting an infection. And since 1871, “normal” has meant 98.6°F (37°C). That number was determined by a German physician, based on millions of readings from 25,000 German patients, taken by sticking thermometers under their arms. When doctors in the U.S. and Europe repeated the experiment in local...
A new drug used as a twice a year injection is being tried out in UK by the NHS as an alternative to statins. Initial reports suggest reduction of bad cholesterol by more than 50 % within weeks of the injection. https://www.bbc.co.uk/news/amp/health-51091083
CONCLUSION: This review highlights some alternatives to address patients' intolerance to statins; however, these are mostly based on recommendations with low to moderate evidence. Therefore, further research with randomized studies involving greater number of patients is required, in order to obtain a more robust recommendation. PMID: 31928603 [PubMed - in process]
Valentina et al.  observed that treatment of patients with atorvastatin significantly improved inflammatory profile in epicardial adipose tissue. This finding may reveal an unexpected role of statin in adipose inflammation, whereas the underlying mechanisms remain unknown.