EPA Overhauls Public Website for Tracking Chemical Safety Review

The U.S. Environmental Protection Agency (EPA) website appears to no longer publish preliminary assessments of potentially hazardous new chemicals, thereby not allowing the public to access information on any initial concerns that the agency may have regarding new chemicals or novel uses for existing chemicals. EPA’s chemical review tracking website was updated on January 5, 2018 with the interim status for more than 120 reviews initiated since September 2017 now showing up as “focus meeting occurred”, indicating only that the staff has had preliminary discussions. Under the Obama administration, EPA would designate an interim status to new chemicals, such as “not likely to present an unreasonable risk” to health or the environment; under “standard review”; unable to be reviewed because of “insufficient information”; or possibly presenting “unreasonable risk of injury”. A final verdict would be delivered after review by the agency within 90 days of receiving relevant documentation from companies. Under the Trump administration, EPA has decided to cut back public access to information about chemical safety. According to a presentation published on the EPA website in December 2017, the agency believed that “previous terminology used for interim statutes created confusion,” and decided to stop updating the online database that was used by the public to track the status of chemical reviews. Jahan ...
Source: Public Policy Reports - Category: Biology Authors: Source Type: news

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Authors: Masouris I, Klein M, Ködel U Abstract INTRODUCTION: Central nervous system (CNS) infections can be life-threatening and are often associated with disabling sequelae. One important factor in most CNS infections is a timely pathogen-specific treatment. The diagnostic methods available, however, do not always reach a satisfying sensitivity and specificity. In these cases, there is need for additional diagnostic biomarkers. Chemokines represent potential candidates as biomarkers, since they are an important pillar of the host immune response. The aim of this review is to discuss the diagnostic potential o...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Publication date: Available online 1 June 2020Source: Biotechnology ReportsAuthor(s): Bouchra Louasté, Noureddine Eloutassi
Source: Biotechnology Reports - Category: Biotechnology Source Type: research
Publication date: Available online 1 June 2020Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): S.R. Saranya, Sudhakaran R
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 1 June 2020Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Jee Yin Cheong, Mustafa Muskhazli, Abd Aziz Nor Azwady, Siti Aqlima Ahmad, Azleen Ahmad Adli
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
OHSU clinicians want to get the word out that it's safe to come in for care.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Discussion and conclusions: M. sirikitiae is a source of cytotoxic lignans and alkaloids. Among the cytotoxic compounds, magnone A and 6-methoxymarcanine A are potentially useful lead compounds for the further development of anticancer agents because of their selective inhibitory effects on cancer cell lines. PMID: 32478640 [PubMed - as supplied by publisher]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Discussion and conclusions: EXD demonstrated neuroprotective effects and improved depression-like behaviour in mice. Further research should be focussed on the mechanism of the active components in EXD. PMID: 32476554 [PubMed - in process]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
This study examined the antihypoxia effects of SPM in vivo.Materials and methods: The dried and pulverised of SPM was extracted from root crude drug with 70% ethanol with ultrasound. Male Sprague-Dawley rats were divided into three groups (n = 10): normal group, hypoxia group (altitude of 4260 m), and hypoxia + SPM group (altitude of 4260 m, SPM of 1.0 g/kg/day). The experiment persisted for 4 weeks. The mean pulmonary arterial pressure (mPAP), hypoxia-inducible factor-1α (HIF-1α) mRNA, and lung pathology were analysed using pulmonary artery pressure recorde...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Authors: Qian X, Wang Z, Ning J, Qin C, Gao L, He N, Lin D, Zhou Z, Li G Abstract Context: Persimmon tannin (extract of Diospyros kaki L.f [Ebenaceae]) and Aloe gel (extract of Aloe vera (L.) Burm.f. [Asphodelaceae]) are known as anti-radiation agents. However, radiation resistance of the persimmon tannin-Aloe gel composite remains inconclusive.Objective: To investigate the capacity of the persimmon tannin-Aloe gel composite to protect against ionising radiation at the cellular level.Materials and methods: HaCaT (human epidermal keratinocytes) cells were pre-treated with PT-A-1 (the mass ratio of persimmon tannin a...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
Conclusion: These results show PSD, R13, and PSA are good candidates as natural products for use in the treatment of lung cancer. Potential signalling pathways and protein targets need to be further validated. The application of the drug combination approach also provides a therapeutic strategy for cancer. PMID: 32476531 [PubMed - in process]
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
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