Crocin improved amyloid beta induced long ‐term potentiation and memory deficits in the hippocampal CA1 neurons in freely moving rats

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• Bilaterally beta‐amyloid (Aβ) administration into the frontal cortex increased memory deficit, which intra‐peritoneal injection of crocin significantly improved Aβ‐induced spatial memory impairment.
• Crocin treatment significantly attenuate c‐Fos level and neuronal apoptosis in hippocampus induced by Aβ administration into the frontal cortex.
• Crocin antagonize the blocking effect of Aβ‐induced LTP deficits in freely moving rat.

Source: Synapse - January 22, 2018 Category: Neurology Authors: Mohammadmehdi Hadipour, Gholamreza Kaka, Farideh Bahrami, Gholam Hossein Meftahi, Gila Pirzad Jahromi, Alireza Mohammadi, Hedayat Sahraei Tags: Research Article Source Type: research