Selective protein unfolding: A universal mechanism of action for the development of irreversible inhibitors

Chem. Commun., 2018, Accepted Manuscript DOI: 10.1039/C8CC00090E, CommunicationPatrick Schaeffer, Samuel Askin, Thomas Bond, Alanna Sorenson, Morgane Moreau, Helma Antony, Rohan A Davis High-throughput differential scanning fluorimetry of GFP-tagged proteins (HT-DSF-GTP) was applied for the identification of novel enzyme inhibitors acting by a mechanism termed: selective protein unfolding (SPU). Four different protein targets... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Chem. Commun. latest articles - January 22, 2018 Category: Chemistry Authors: Patrick Schaeffer Source Type: research