The Reply

We appreciate the interest of Ayubi and colleagues in our study.1 As the authors highlighted, the aim of this study was to determine the impact of migraine on long-term outcomes in a cohort of women with suspected myocardial ischemia. We agree that use of composite outcomes improves statistical power, but it also provides a more complete picture of the overall influence of a disorder (like migraine) on the cardiovascular system. Our choice was also consistent with prior studies that investigated the impact of migraine on cardiovascular events using a composite outcome.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Letter Source Type: research