The physical spacing between the von Willebrand factor D'D3 and A1 domains regulates platelet adhesion in  vitro and in vivo

ConclusionConformation changes at the VWF D'D3‐A1 interface may be a key regulator of thrombosis in vivo. Structural features at the A1‐A2 interface are likely of less significance.

Source: Journal of Thrombosis and Haemostasis - January 22, 2018 Category: Hematology Authors: C. Zhang, A. Kelkar, M. Nasirikenari, J. T. Y. Lau, M. Sveinsson, U. C. Sharma, S. Pokharel, S. Neelamegham Tags: Original Article Source Type: research