Targeting of the AKT/m-TOR Pathway: Biomarkers of Resistance to Cancer Therapy ——
AKT/m-TOR Pathway and Resistance to Cancer Therapy

Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers associated with resistance. The conflicting data were reported regarding the AKT/m-TOR signaling pathway components as markers predicting resistance. The AKT/m-TOR signaling pathway is involved in the development of many human cancers; its activation is related to cell proliferation, angiogenesis, apoptosis, as well as to therapy resistance. Molecular alterations in the AKT/m-TOR signaling pathway provide a platform to identify universal markers associated with the development of resistance to cancer therapy. DOI: 10.3779/j.issn.1009-3419.2018.01.09
Source: Chinese Journal of Lung Cancer - Category: Cancer & Oncology Source Type: research