mRNA Translation Gone Awry: Translation Fidelity and Neurological Disease.

mRNA Translation Gone Awry: Translation Fidelity and Neurological Disease.
Trends Genet. 2018 Jan 15;:
Authors: Kapur M, Ackerman SL
Abstract
Errors during mRNA translation can lead to a reduction in the levels of functional proteins and an increase in deleterious molecules. Advances in next-generation sequencing have led to the discovery of rare genetic disorders, many caused by mutations in genes encoding the mRNA translation machinery, as well as to a better understanding of translational dynamics through ribosome profiling. We discuss here multiple neurological disorders that are linked to errors in tRNA aminoacylation and ribosome decoding. We draw on studies from genetic models, including yeast and mice, to enhance our understanding of the translational defects observed in these diseases. Finally, we emphasize the importance of tRNA, their associated enzymes, and the inextricable link between accuracy and efficiency in the maintenance of translational fidelity.
PMID: 29352613 [PubMed - as supplied by publisher]

Source: Trends in Genetics : TIG - January 15, 2018 Category: Genetics & Stem Cells Authors: Kapur M, Ackerman SL Tags: Trends Genet Source Type: research