Fight Aging! Newsletter, January 22nd 2018

In conclusion, death is a natural part of human existence, but human progress is essentially a story of overcoming undesirable natural limits. In the near future, technological progress might make it possible to stop natural biological death. Should humankind embrace such technology? Yes: Even though such technology would not be without risks, the risks are almost certainly manageable. The benefits of ending natural death, on the other hand, are immense. Death is an obstacle that is slowing down human progress. If we remove that obstacle, humankind could increase the speed of both its moral and its epistemic progress. An Attempt at Using Protein Levels Rather than Epigenetic Patterns to Build a Biomarker of Aging https://www.fightaging.org/archives/2018/01/an-attempt-at-using-protein-levels-rather-than-epigenetic-patterns-to-build-a-biomarker-of-aging/ The current best candidates for a sufficiently robust biomarker of aging are based on patterns of DNA methylation, epigenetic markers that control the pace at which specific proteins are produced, and which are constantly shifting in response to circumstances. The best of these epigenetic clocks have degrees of error in assessed age that are five years or less, depending on implementation. The researchers here have chosen to investigate patterns of protein levels in blood rather than epigenetic markers, in part driven by economic considerations, as the needed tools of biotechnology are more mature and less e...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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Date: Wednesday, 07 17, 2019; Speaker: Mary Kearney, PhD, Head, Translational Research Unite, HIV Dynamics and Replication Program, Center, National Cancer Institute; https://bit.ly/2RyT8Kw
Source: NIH Calendar of Events - Category: American Health Source Type: events
Publication date: Available online 23 June 2019Source: Physica E: Low-dimensional Systems and NanostructuresAuthor(s): Sahel Karoui, Hassen Chouaib, Slaheddine KamounAbstractThe [C4H10NH2]2SnCl6 compound is characterized by using the X-ray powder analysis, thermogravimetric analysis, differential scanning calorimetry analysis, 13C and 119Sn (CP/MAS NMR) analysis, vibrational spectroscopy and complex impedance spectroscopic data. The results show that this compound exhibits a phase transition at 326 K which was characterized by differential scanning calorimetry (DSC), X-rays powder diffraction, Raman spectroscopy and diel...
Source: Physica E: Low dimensional Systems and Nanostructures - Category: Nanotechnology Source Type: research
In this study, we constructed a dual function nanosystem, copper sulfide nanoplatform loaded with the chemotherapeutic drug docetaxel wrapped by a conjugated polymer-peptide for targeted chemo-phototherapy. The nanoconstruct has been successfully designed with a size of 186.1 ± 5.2 nm, a polydispersity index of 0.18 ± 0.01, and zeta potential of −16.4 ± 0.1 mV. The enhanced uptake and near-infrared-responsive behavior of the nanosystem resulted in efficient drug release, photothermal ablation, effective cytotoxic activity, and potentiated reactive oxygen sp...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): C.G. Moura, O. Carvalho, L.M.V. Gonçalves, M.F. Cerqueira, R. Nascimento, F. SilvaAbstractThe development of smart biomedical implants with intrinsic communication system between sensors and actuators, or between implant and patient, remains a challenge for scientific community. Titanium and its alloys, especially Ti6Al4V, are the most used materials in the implant's fabrication. The present work is concerned with implant internal communication printing process and presents a detailed study on titanium alloy (Ti6Al4V) s...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
ConclusionAs a composite scaffold, an NT-3 sustained-release system cross-linked with an acellular spinal cord scaffold has potential applications for tissue engineering.Graphical abstract
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 22 June 2019Source: Materials Science and Engineering: AAuthor(s): Xiao Ding, Yuichiro Koizumi, Kenta Aoyagi, Tadashi Kii, Nobuyuki Sasaki, Yuichiro Hayasaka, Kenta Yamanaka, Akihiko ChibaAbstractThis paper presents microstructures of Inconel 718 fabricated by electron beam melting (EBM), a powder bed fusion (PBF), additive manufacturing (AM) process, under various conditions with an extended range of electron beam power (P) and scanning speed (V). An adaptive offset method (AOM) was used to optimize the beam scanning line offset adaptively to fabricate blocks without macroscopic defects....
Source: Materials Science and Engineering: A - Category: Materials Science Source Type: research
Publication date: October 2019Source: Scripta Materialia, Volume 171Author(s): Qiumei Wei, Mankang Zhu, Mupeng Zheng, Yudong Hou, Junjie Li, Yang BaiAbstractHere, we show the large electrocaloric effect near room temperature in ergodic relaxor (Bi1/2Na1/2)0.93Ba0.07(Zn1/3Nb2/3)0.01Ti0.99O3 (BNBZN) observed by a modified differential scanning calorimeter. Microstructure analysis revealed that BNBZN sample demonstrates global pseudocubic structure with locally distorted structures. Electric measurements showed that the sample coexists of two types of polar nanoregions (PNRs) with different coupling ability, and behaves as er...
Source: Scripta Materialia - Category: Materials Science Source Type: research
Publication date: Available online 22 June 2019Source: NeuroImageAuthor(s): Martin Sjøgård, Xavier De Tiège, Alison Mary, Philippe Peigneux, Serge Goldman, Guy Nagels, Jeroen van Schependom, Andrew J. Quinn, Mark Woolrich, Vincent WensAbstractThe default-mode network (DMN) and its principal core hubs in the posterior midline cortices (PMC), i.e., the precuneus and the posterior cingulate cortex, play a critical role in the human brain structural and functional architecture. Because of their centrality, they are affected by a wide spectrum of brain disorders, e.g., Alzheimer's disease. Non-invasive elect...
Source: NeuroImage - Category: Neuroscience Source Type: research
We examined the U.S. thoracic surgery workforce using the 2010 and 2014 Area Health Resource Files. We calculated the density of thoracic surgeons per 100,000 persons for each year at the state and county level. We performed descriptive statistics and developed maps highlighting changes over time and geographic regions.ResultsDespite an overall increase in thoracic surgeons from 2010 to 2014, we observed declining density nationwide (1.5% change) and in sparsely populated states. The difference in thoracic surgeon density widened slightly between 2010 from 0.80 per 100,000 compared to 0.84 per 100,000 in 2014 in all rural ...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: Available online 22 June 2019Source: The Annals of Thoracic SurgeryAuthor(s): Dmitry B. Giller, Galina V. Giller, Boris D. Giller, Alexander V. Papkov, Galina V. Scherbakova, Vadim V. Koroev, Oleg Sh. KesaevAbstractA patient with extensive fibro-cavitary pulmonary tuberculosis (TB) and extensively drug-resistant (XDR) Mycobacterium tuberculosis (MTB) underwent bilateral VATS thoracoplasty. An examination four years post-surgery revealed that the patient was in a satisfactory condition and able-bodied.We performed surgery according to our proposed VATS thoracoplasty technique. In the postoperative period, ...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
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