Resolvin E1, resolvin D1 and resolvin D2 inhibit constriction of rat thoracic aorta and human pulmonary artery induced by the thromboxane mimetic U46619.

Conclusion and ImplicationsThese data suggest that resolvins or their mimetics may prove useful novel therapeutics in diseases such as pulmonary arterial hypertension, which are characterised by increased thromboxane contractile activity.

Source: British Journal of Pharmacology - January 21, 2018 Category: Drugs & Pharmacology Authors: Melanie Jannaway, Christopher Torrens, Jane A Warner, Anthony P Sampson Tags: RESEARCH PAPER Source Type: research