Cyclophilin D Deficiency Attenuates Mitochondrial Perturbation and Ameliorates Hepatic Steatosis

Conclusion: CypD stimulates mPTP excessive opening, subsequently causing endoplasmic reticulum (ER) stress via p38 MAPK activation, and resultes in enhanced SREBP‐1c transcription and hepatic steatosis. This article is protected by copyright. All rights reserved.

Source: Hepatology - January 21, 2018 Category: Internal Medicine Authors: Xiaolei Wang, Heng Du, Shanshan Shao, Tao Bo, Chunxiao Yu, Wenbin Chen, Lifang Zhao, Qiu Li, Li Wang, Xiaojing Liu, Xiaohui Su, Mingqi Sun, Yongfeng Song, Ling Gao, Jiajun Zhao Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research