High yield of pathogenic germline mutations causative or likely causative of the cancer phenotype in selected children with cancer.

CONCLUSION: In our selected cohort of patients, pathogenic germline mutations causative or likely causative of the cancer phenotype were found in eight patients and two possible novel cancer predisposing genes were identified. Therewith, our study shows the added value of sequencing beyond a cancer gene panel in selected patients, to recognize childhood cancer predisposition.
PMID: 29351919 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - January 19, 2018 Category: Cancer & Oncology Authors: Diets I, Waanders E, Ligtenberg MJL, Bladel DV, Kamping EJ, Hoogerbrugge PM, Hopman S, Olderode-Berends MJW, Gerkes EH, Koolen D, Marcelis C, Santen GW, Belzen MV, Mordaunt D, McGregor L, Thompson E, Kattamis A, Pastorczak A, Mlynarski W, Ilencikova D, Vu Tags: Clin Cancer Res Source Type: research