Diagnostic and prognostic micro-RNAs in ischemic stroke due to carotid artery stenosis and in acute coronary syndrome: the 4-year prospective study.

Diagnostic and prognostic micro-RNAs in ischemic stroke due to carotid artery stenosis and in acute coronary syndrome: the 4-year prospective study. Kardiol Pol. 2018 Jan 19;: Authors: Gacoń J, Badacz R, Stępień E, Karch I, Enguita FJ, Żmudka K, Przewłocki T, Kabłak-Ziembicka A Abstract BACKGROUND: Circulating microRNAs (miRs) levels are potentially important diagnostic and prognostic biomarkers in acute coronary syndrome (ACS) or cerebral ischemic event (CIE) resulting from internal carotid artery stenosis (ICAS). AIM: This 4-year prospective study aimed to compare the levels of circulating miRs in ACS vs CIE patients, and investigate miRs potentially associated with risk of recurrent cardiovascular event. METHODS: The circulating miRs levels (miR-1-3p, miR-16-5p, miR-34a-5p, mir-122-5p, miR-124-3p, miR-133a-3p, miR-133b, miR-134-5p, miR-208b-3p, miR-375 and miR-499-5p) were compared in 43 (34M, 57.6±10.1y.) patients with ACS, and in 71 (47M, 69.5±9.6y) with CIE due to ICAS. A 4-year prospective evaluation of miRs associated with risk of cardiovascular death (CVD), myocardial infarction (MI), CIE, or all (CVD/MI/CIE) was performed. RESULTS: In ACS vs. CIE patients, the levels of miR-124-3p (p. PMID: 29350392 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - Category: Cardiology Authors: Tags: Kardiol Pol Source Type: research