Metallic gold and bioactive Quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner

Complete eradication of aggressive oral cancer remains a challenge due to the presence of CSCs. They resist to conventional chemotherapeutic agents due to their self-renewal, drug efflux, and efficient DNA repair capacity. Here, we formulated a hybrid-nanoparticle (QAuNP) using quinacrine and gold and characterized; investigated its anti-angiogenic and anti-metastatic effect on OSCC-CSCs. QAuNP significantly inhibited cellular proliferation, caused apoptosis in vitro, disrupted angiogenesis in vivo and tumor regression in xenograft mice model.

Source: Nanomedicine : Nanotechnology, Biology, and Medicine - January 21, 2018 Category: Nanotechnology Authors: Shakti Ranjan Satapathy, Anmada Nayak, Sumit Siddharth, Sarita Das, Deepika Nayak, Chanakya Nath Kundu Source Type: research