A three-dimensional correction method for predicting the readings of a PinPoint chamber on the CyberKnife ® M6 ™ machine.

Conclusion: These results demonstrate the existence and efficiency of the novel 3D correction method for small field dosimetry. The 3D correction method provides an access to evaluate the clinical measurement data and can be applied to non-standard composite fields IMRT point dose verification. . PMID: 29350197 [PubMed - as supplied by publisher]
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research

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ConclusionFor planners A and B, the usage of PlanIQ did not show a great improvement in the sparing of organs-at-risk whereas for planner C it made a major difference. In any case, PlanIQ contributed to a lower plan quality output variability among the different planners.
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
AbstractProstate cancer is the most common cancer among men in the USA. Interestingly, recent studies suggest that patients with inflammatory bowel disease (IBD) are at increased risk of developing prostate cancer. Importantly, patients with IBD who develop prostate cancer require thoughtful care when using immunosuppressants to treat the IBD in the setting of malignancy. Further, consideration must be given to the proximity of the prostate to the gastrointestinal tract when treating with radiation where there is concern for the effects of inadvertent exposure of radiation to the diseased bowel. In general, management of i...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
CONCLUSION: RT comprises an effective treatment modality of benign brain and intracranial lesions. By minimizing its ares with optimal use, RT projects as a potent tool against such diseases. PMID: 31713498 [PubMed - as supplied by publisher]
Source: Reviews on Recent Clinical Trials - Category: Cancer & Oncology Authors: Tags: Rev Recent Clin Trials Source Type: research
Publication date: February 2020Source: Safety Science, Volume 122Author(s): Natalia Silvis-Cividjian, Wilko Verbakel, Marjan AdmiraalAbstractRadiation therapy is an important technique to treat cancer. Due to the high occupational risks involved, the process is subject to severe safety regulations and standards. However, these standards do not mandate the usage of a particular hazard analysis method. The de facto methods currently used are the reliability theory-based Fault Tree Analysis (FTA) and Healthcare Failure Mode and Effects Analysis (HFMEA). Systems Theoretic Process Analysis (STPA) is a new, essentially different...
Source: Safety Science - Category: Occupational Health Source Type: research
To evaluate the results of the concurrent use of lenalidomide-dexamethasone with intensity-modulated radiation therapy (IMRT) for solitary plasmacytoma in terms of toxicity and outcomeMaterials&Methods: Forty-six patients were treated for histologically proven SP between June 2007 and June 2018 in our Department (XXX). All patients received IMRT. The median total dose was 40 Gy (range, 40-46). Prescription of concurrent lenalidomide-dexamethasone with radiotherapy was left discretion of the referring hematologist-oncologist and started the first day of radiotherapy for four cycles.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
We present a case of a large clival chordoma in a 54-year-old female with a past medical history of Turner's syndrome and a 1.5-year history of nasal congestion. The tumor was extending in the nasopharynx to both pterygopalatine fossae. An expanded endoscopic endonasal approach was selected. Stereotactic navigation was utilized. Bilateral transmaxillary approach with ethmoidectomy was performed, and a transclival corridor to the deepest portion of the tumor was created. The tumor was successfully dissected off the medial walls of the cavernous sinuses. Gross-macroscopic resection was achieved. Surgical reconstruction of th...
Source: Journal of Neurological Surgery Part B: Skull Base - Category: Neurosurgery Authors: Tags: Skull Base: Operative Videos Source Type: research
Publication date: November–December 2019Source: Reports of Practical Oncology &Radiotherapy, Volume 24, Issue 6Author(s): Ram Abhinav Kannan, TR Arul PonniAbstractAimTo analyse the long term swallowing function in head and neck cancer patients and correlate with the dose to midline swallowing structures.BackgroundThe use of concurrent chemo radiation (CRT) as the present standard of care resulted in high rates of early and late toxicities. Dysphagia, aspiration, and xerostomia are early as well as late effects of radiation. Not many studies on the dysphagia scores during radiation and follow-up period have correl...
Source: Reports of Practical Oncology and Radiotherapy - Category: Cancer & Oncology Source Type: research
AbstractPurposeTo compare the clinical results and functional outcomes between two-dimensional conventional radiation therapy (2DRT) and intensity-modulated radiation therapy (IMRT) in nasopharyngeal carcinoma (NPC) with skull-base invasion.MethodsA total of 1258 patients were subclassified into two groups: mild skull-base invasion group (792; 63%) and severe skull-base invasion group (466; 37%). Patients were pair matched (1:1 ratio) using six clinical factors into 2DRT or IMRT groups. The Kaplan –Meier method and Cox regression model were performed to assess overall survival (OS), disease-free survival (DFS), locor...
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
This article describes the evolution of the role of radiation therapy from nonimmunotherapy to the era of immunotherapy.
Source: Surgical Clinics of North America - Category: Surgery Authors: Source Type: research
This is a single-institution phase I study that evaluated the addition of BYL719, an α-specific PI3K inhibitor, to cetuximab and intensity-modulated radiation therapy (IMRT) in patients with stage III-IVB head and neck squamous cell carcinoma. The recommended phase II dose of BYL719 was found to be 250 mg/day in combination with cetuximab and IMRT. Related grade> 3 adverse events included decreased lymphocyte count, oral mucositis, dysphagia, hyperglycemia, maculopapular rash, and palmar-plantar erythrodysesthesia syndrome.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
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