Association of long pentraxin-3 with pulmonary hypertension and primary graft dysfunction in lung transplant recipients

Primary graft dysfunction (PGD), a form of severe acute lung injury, is the main cause of early morbidity and mortality after lung transplantation. Pulmonary hypertension (PH), either World Health Organization (WHO) Group I or III, is a significant risk factor for PGD.1 We previously demonstrated that genetic variation in long pentraxin-3 (PTX3), a phylogenetically conserved acute-phase reactant that modulates inflammatory responses, and elevated post-transplant plasma PTX3 levels were associated with an increased risk of PGD after lung transplantation.

Source: The Journal of Heart and Lung Transplantation - December 20, 2017 Category: Transplant Surgery Authors: Joshua M. Diamond, Kristy Ramphal, Mary K. Porteous, Edward Cantu, Jason D. Christie, Steven M. Kawut, for the Lung Transplant Outcomes Group Tags: Research Correspondence Source Type: research