The role of NAFLD in extrahepatic malignancies: the importance of ruling out the effect of obesity

We read with great interests the article by Gi-Ae et al[1]. Non-alcoholic fatty liver disease(NAFLD) is strongly associated with metabolic disorders such as insulin resistance, diabetes and cardiovascular diseases which implies that NAFLD might have an important part in extrahepatic complications. Gi-Ae et al not only confirmed that NAFLD is closely related to the development of hepatocellular carcinoma but also demonstrated that NAFLD is a risk factor for extrahepatic malignancies such as male colorectal carcinoma and female breast cancer.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research

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Publication date: Available online 17 August 2018Source: Journal of Visceral SurgeryAuthor(s): T. Sarcher, B. Dupont, A. Alves, B. MenahemSummaryMultidisciplinary management of infra-peritoneal rectal cancer has pushed back the frontiers of sphincter preservation, without impairment of carcinological outcome. However, functional intestinal sequelae, grouping together several symptoms known under the name of anterior resection syndrome (ARS), have emerged and become an increasingly frequent concern for both patients and physicians. The pathophysiology is complex: ARS is a combination in various degrees of stool frequency, i...
Source: Journal of Visceral Surgery - Category: Surgery Source Type: research
ConclusionExploring perspectives in LARS patients resulted in the identification of potential improvements in current care pathways. Recommendations on ways to improve information provision, screening of LARS and methods to intervene in the gap of supportive care after discharge are presented. We recommend to implement these measures as QoL of patients undergoing colorectal cancer surgery may be improved.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
In this study, we compared perioperative and oncologic outcomes of patients treated with either open or robot-assisted radical cystectomy and intracorporeal neobladder at a tertiary care center.MethodsThe institutional prospective bladder cancer database was queried for “cystectomy with curative intent” and “neobladder”. All patients underwent robot-assisted radical cystectomy and intracorporeal neobladder or open radical cystectomy and orthotopic neobladder for high-grade non-muscle invasive bladder cancer or muscle invasive bladder cancer with a follow-up length ≥2 years were included. A 1:1 pr...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionBoth types of organ-sparing surgeries assessed in this study achieved good outcomes, in terms of the aesthetics, sexual functions, urinary functions, and HRQOL in patients, without compromising the therapeutic effects of these surgeries. However, the observed decreases in orgasmic function will need to be addressed further.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: September 2018Source: European Journal of Surgical Oncology, Volume 44, Issue 9Author(s): Ricard Ramos, Ernest Nadal, Inma Peiró, Cristina Masuet-Aumatell, Ivan Macia, Francisco Rivas, Gabriela Rosado, Pau Rodriguez, Anna Ureña, Susana Padrones, Samantha Aso, Carlos Deniz, Arturo Navarro, Ignacio EscobarAbstractBackgroundAs nutritional status plays an important role in outcomes after surgery, this study evaluated the association between preoperative nutritional status (NS) and postoperative outcomes after major resection for lung cancer.MethodsWe identified 219 patients with a diagnosis of c...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionsThe EORTC-STBSG response score is applicable for determining the histopathological response to neoadjuvant ESTS treatment. However, this response does not seem to predict LRFS nor OS in locally advanced ESTS.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: September 2018Source: European Journal of Surgical Oncology, Volume 44, Issue 9Author(s): A.J. Breugom, E. Bastiaannet, P.G. Boelens, E. Van Eycken, L.H. Iversen, A. Martling, R. Johansson, T. Evans, S. Lawton, K.M. O'Brien, H. Ortiz, R. Janciauskiene, O.M. Dekkers, H.J.T. Rutten, G.J. Liefers, V.E.P.P. Lemmens, C.J.H. van de VeldeAbstractIntroductionThe aim of this EURECCA international comparison is to compare oncologic treatment strategies and relative survival of patients with stage I–III rectal cancer between European countries.Material and methodsPopulation-based national cohort data from the ...
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionsThis study indicates that the implementation and assurance of evidence-based quality standards has substantial positive effects on various patient-relevant outcomes in colon cancer care.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionsIn our experience minimally invasive surgery is a valid therapeutic approach in very select patients with localized lymph-nodal recurrence of gynecological cancers, with benefits about peri and post-operative morbidities and without compromising their oncological outcome.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
We report of a case rapid onset systemic sclerosis complicated by acute renal failure and diffuse alveolar hemorrhage in a woman with stage IIB right breast cancer and elevated RNA Polymerase III IgG Ab. To our knowledge, this the first case of a patient with breast cancer associated with systemic sclerosis and pulmonary-renal syndrome.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
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