Podophyllotoxin in Dermatology

This article describes the features of podophyllotoxin, utilized in diluted solution as podofilox, a topical treatment for external genital warts, such as condylomata acuminata.
Source: JDNA: Journal of the Dermatology Nurses Association - Category: Dermatology Tags: DEPARTMENTS: Drugs in Dermatology Source Type: research

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In this study, we re port a library of 73 novel psoralens, the largest collection of its kind. When screened for the ability to induce cell death, we identified two derivatives even more cytotoxic than 4’‐aminomethyl‐4,5’,8‐trimethylpsoralen (AMT), one of the most potent psoralens identified to date. Using MAL DI‐TOF MS, we studied the DNA adduct formation of a subset of novel psoralens and found that in most cases enhanced DNA binding correlated well with cytotoxicity. Generally, our most active derivatives contain positively charged substituents, which we believe increase DNA affinity and enhance psor...
Source: Photochemistry and Photobiology - Category: Science Authors: Tags: RESEARCH ARTICLE Source Type: research
Publication date: Available online 29 March 2020Source: Actas Dermo-Sifiliográficas (English Edition)Author(s): A. Fernandez-Flores, M. Llamas Velasco, M. Saeb Lima
Source: Actas Dermo-Sifiliograficas - Category: Dermatology Source Type: research
Conclusion: Palmoplantar pustulosis appears to be a distinct entity from psoriasis. Routine thyroid functions test could be analyzed, but patch testing is not required in patients with palmoplantar pustulosis. Also, patients with palmoplantar pustulosis must be evaluated for musculoskeletal symptoms and signs.
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
Conclusion: This is the first Argentine study that evaluated the costs of moderate/severe psoriasis by taking into consideration the direct medical costs of the disease.
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
Conclusion: CYP2J2 50G>T (rs890293) polymorphism was associated with an increased risk for PsV in the Turkish population.
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
The objective of this retrospective study is to assess the C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio as inflammatory markers in patients with psoriasis and to search for a relationship between these parameters and psoriasis severity, as defined by the psoriasis area and severity index. Methods: There were 94 patients with psoriasis and 118 healthy controls enrolled in the study. The C-reactive protein, monocyte-to-high-density-lipoprotein ratio, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, a...
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
Abstract The number of individuals with tattoos has been increasing worldwide, alongside with reports of complications varying from reactions to the injected pigments to infections caused by agents inoculated in the pigmentation process. The diagnosis of such unwanted events can be obtained through complementary non-invasive methods, preserving the maximum of the tattoo design. The authors present two cases of patients with warts on tattooing, and correlate their clinical aspects to in vivo and ex vivo dermoscopy, and to the findings in the histopathological examination, aiming to determine patterns that aid the diagnosis ...
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
Abstract White fibrous papulosis of the neck is a rare entity, with fewer than 50 cases described. It is a benign pathology whose main interest lies in its broad differential diagnosis, especially with pseudoxanthoma elasticum. The authors report the case of a 77-year-old woman with multiple yellow-white monomorphic papules on the posterior cervical region, with years of evolution. Cutaneous biopsy revealed a nodular area in the superficial and middle reticular dermis, with slight thickening of the collagen fibers and focally enlarged elastic fibers, aspects highlighted in the Verhoeff staining that additionally showed abs...
Source: Anais Brasileiros de Dermatologia - Category: Dermatology Source Type: research
CONCLUSIONS: The diagnoses made were described, including their associations with non-circumcision and atopy. Several of these observations have not been recognised before in the literature. We discuss lessons learned in the management of male genital disease and its psychosocial impact. PMID: 27170096 [PubMed - as supplied by publisher]
Source: The Australasian Journal of Dermatology - Category: Dermatology Authors: Tags: Australas J Dermatol Source Type: research
ConclusionsThe diagnoses made were described, including their associations with non‐circumcision and atopy. Several of these observations have not been recognised before in the literature. We discuss lessons learned in the management of male genital disease and its psychosocial impact.
Source: Australasian Journal of Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
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