Resting Functional Connectivity of the Periaqueductal Gray is Associated with Normal Inhibition and Pathological Facilitation in Conditioned Pain Modulation
• Conditioned pain modulation (CPM) facilitation observed in fibromyalgia patients• Smaller periaqueducal gray (PAG) volume observed in fibromyalgia patients• PAG resting connectivity with cortical areas associated with pain inhibition• PAG-to-brainstem connectivity helps explain CPM facilit ation in fibromyalgia• Consistent with pathological pain-facilitative brainstem mechanisms found in animals
Source: The Journal of Pain - Category: Materials Science Authors: Daniel E. Harper, Eric Ichesco, Andrew Schrepf, Johnson P. Hampson, Daniel J. Clauw, Tobias Schmidt-Wilcke, Richard E. Harris, Steven E. Harte Tags: Original Report Source Type: research