Does breast density measured through population-based screening independently increase breast cancer risk in Asian females?

Does breast density measured through population-based screening independently increase breast cancer risk in Asian females? Clin Epidemiol. 2018;10:61-70 Authors: Park B, Cho HM, Lee EH, Song S, Suh M, Choi KS, Kang BJ, Ko K, Yi A, Jung HK, Cha JH, Jun JK Abstract Purpose: The purpose of this study was to investigate the effects of breast density on breast cancer risk among women screened via a nationwide mammographic screening program. Patients and methods: We conducted a nested case-control study for a randomly selected population of 1,561 breast cancer patients and 6,002 matched controls from the National Cancer Screening Program. Breast density was measured and recorded by two independent radiologists using the Breast Imaging Reporting and Data System (BI-RADS). Associations between BI-RADS density and breast cancer risk were evaluated according to screening results, time elapsed since receiving non-recall results, age, and menopausal status after adjusting for possible covariates. Results: Breast cancer risk for women with extremely dense breasts was five times higher (adjusted odds ratio [aOR] =5.0; 95% confidence interval [CI]) =3.7-6.7) than that for women with an almost entirely fatty breast, although the risk differed between recalled women (aOR =3.3, 95% CI =2.3-3.6) and women with non-recalled results (aOR =12.1, 95% CI =6.3-23.3, P-heterogeneity =0.001). aORs for BI-RADS categories of breast density were similar when subjects who d...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Clin Epidemiol Source Type: research

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This study analyzed data from women over 40 and compared the size of breast cancers at the time of diagnosis detected in the 1970s (before mammography became common) with the size of tumors detected between 2000 and 2002, when screening mammography was routine. Treatments and rates of death due to breast cancer 10 years after the diagnosis were also analyzed. The study found that: As more women underwent routine screening mammograms, more small breast cancers were detected. Many of these tumors were restricted to the ducts within the breast (called ductal carcinoma in situ), and even without treatment would never threaten...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Source Type: blogs
ConclusionReproductive risk factors significantly influence the epithelial tissue compartment and expression of hormone receptors in later life. These changes remain after menopause. This study provides deeper insights of the biological mechanisms by which reproductive history influences epithelial area and expression of hormone receptors, and as a consequence the risk of breast cancer.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
Conclusions: Low-dose vaginal estrogen use for 1 or more years in a small cohort of women with GSM did not appear to be associated with any changes in breast density or Bi-RADS breast cancer risk scores in the majority of study participants, including three breast cancer survivors. Larger long-term controlled clinical trials should be conducted to examine the effects of low-dose vaginal estrogen on mammographic density in women with and without a personal history of breast cancer. Furthermore, relative efficacy and risk of vaginal estrogen compared with other forms of treatment for GSM should also be studied in long-term trials.
Source: Menopause - Category: OBGYN Tags: Brief Report Source Type: research
ConclusionBreast density is an independent and significant risk factor for development of contralateral breast cancer. This risk factor should contribute to clinical decision making.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionsOur results do not support associations between T2DM and/or GDM and higher amount of mammographically dense breast tissue, suggesting that the mechanism linking diabetes with breast cancer risk may not include mammographic breast density  in midlife.
Source: Cancer Causes and Control - Category: Cancer & Oncology Source Type: research
Abstract OBJECTIVE: To evaluate the impact of background parenchymal enhancement (BPE) on breast MRI and pathological tumor responses to neoadjuvant chemotherapy (NAC) in breast cancer patients. METHODS: A panel of 372 MRI from 186 pathologically confirmed breast cancer patients who underwent breast MRI before and after NAC were selected. BPE was classified into four categories before and after NAC. The association between BPE and the pathological tumor response to NAC, recurrence-free survival (RFS) and molecular subtypes were analyzed. We also evaluated the associations between the baseline BPE before NAC a...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
Conclusions: This pilot study indicated that the uptake of gastrin-releasing peptide receptor antagonist 68Ga-NOTA-RM26 may correlate with ER expression in breast cancer. To avoid the physiological uptake of 68Ga-NOTA-RM26 in normal breast tissue, it is suggested that this examination not be performed during the secretory phase of the menstrual cycle. Figure legend: Figure 1. A 60-year-old patient with breast invasive ductal carcinoma showed intense 68Ga-RM26 uptake in the primary tumor (blue arrows) and lymph node metastasis (yellow arrows) on the left side. The tumor stained positively for ER (F) and GRPR (G); the lymph ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Breast Cancer: Novel Tracers, Response Biomarkers, and Therapy Source Type: research
Conclusions:Our results showed a high compliance rate with fasting and warming instructions, however, findings suggest that a 3-hour fast and warming of the upper torso, does not result in significant improvements in image count density in the clinical environment. These findings are in contrast to count density improvements observed in a controlled research study as a function of fasting or warming, where serial examinations were assessed within the same patient. A limitation of the current analysis conducted in clinical practice is that fasting status is patient-reported and time spent warming is patient-directed, which ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: TS17: Student Tech Papers I Source Type: research
This study was aimed to evaluate breast cancer screening determinants in women referred to health centers of Urmia for mammography in 2017. Materials and Methods: In this descriptive-analytic cross-sectional study, 348 women referred to health centers of Urmia were selected using multistage sampling. Data were collected using a standard questionnaire for mammography screening determinants, with a checklist including demographic characteristics, family, social and economic factors and midwifery background. Analysis was with SPSS software version 20for descriptive and inferential statistic tests, P
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
This study aimed to clarify the relationship between MD and breast cancer subtypes defined by tumor markers. We enrolled 642 women with breast cancer (69% premenopausal) and 1241 controls matched for age and menopausal status. Absolute mammographic dense area (ADA), percent mammographic dense area (PDA), and nondense area were assessed using a computer-assisted thresholding technique. We classified breast cancer cases into four subtypes using information on tumor marker expression such as estrogen receptor (ER), progesterone receptor (PR), and Cerb2 receptor (HER2); luminal A (ER+ and/or PR+, HER2−), luminal B (ER+ a...
Source: European Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Research Paper: Breast Cancer Source Type: research
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