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Accurate understanding of infertility risk among families of adolescent males newly diagnosed with cancer

ConclusionsMost adolescents and parents inaccurately reported infertility risk, and more poorly estimated risk. Research is needed to identify additional factors associated with accurate understanding of cancer‐related infertility risk. Providers should be supported with user‐friendly educational tools to promote awareness of infertility risk.
Source: Psycho-Oncology - Category: Cancer & Oncology Authors: Tags: PAPER Source Type: research

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UCLA researchers have made new inroads into understanding germ cell tumors, a diverse and rare group of cancers that begin in germ cells — the cells that develop into sperm and eggs. The researchers developed a protocol to recreate germ cell tumor cells from stem cells and used the new model to study the genetics of the cancer.Their findings could point the way toward new drugs to treat germ cell tumors, which account for around 3 percent of all cases of childhood and adolescent cancer.The study, published in Stem Cell Research, was led by Amander Clark, a UCLA professor of molecular cell and developmental biology an...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
This is one of my pet peeves. Children with cancer have their mature, sane parents advocating for them. Adults with cancer can advocate for themselves.The young adults - 15 to 30s - often don't find the same support or resources. First they are still trying to figure out who they are and what they will do with their life. Second, they are learning to be independent and should be focusing on their education and careers, not going to chemotherapy. There is hope now that online resources can help fill the gaps for the patients and maybe for the doctors as well." In addition, they will probably go on to live long lives an...
Source: Caroline's Breast Cancer Blog - Category: Cancer & Oncology Tags: cancer bonds cancer treatment side effects young cancer patients Source Type: blogs
Both pediatric oncologists and reproductive urologists share a joint responsibility to educate, treat, and advocate for male adolescent and young adult (AYA) cancer patients who require gonadotoxic therapy. The importance of fertility preservation coincides with the ever-growing number of pediatric cancer survivors, because most children now survive their malignancy into adulthood and ultimately desire family building. Unfortunately, the risk of infertility in this population is remarkably high.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
Publication date: Available online 26 October 2017 Source:Best Practice & Research Clinical Obstetrics & Gynaecology Author(s): Gabriela N. Algarroba, Joseph S. Sanfilippo, Hanna Valli-Pulaski The 5-year survival rate for childhood cancer is over 80%, thereby increasing the number of young women facing infertility in the future due to the gonadotoxic effects of chemotherapy and radiation. The gonadotoxic effects of childhood cancer treatment vary by the radiation regimen and the chemotherapeutic drugs utilized. Although the American Society of Clinical Oncology guidelines recommend fertility preservation for all p...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research
In this study, we validated the feasibility of survey administration and identified trends in oncofertility counseling at our center. PMID: 29058500 [PubMed - as supplied by publisher]
Source: Ann Oncol - Category: Cancer & Oncology Authors: Tags: J Adolesc Young Adult Oncol Source Type: research
ConclusionsBiological parenthood was important to this cohort yet fertility and reproductive health knowledge was low, suggesting that clinicians should prioritize conversations about infertility risk and birth control options with AYA with SCD on hydroxyurea and their caregivers.  More research is needed to identify optimal approaches to these discussions.
Source: Pediatric Blood and Cancer - Category: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research
Discussion Of the 30 different microbes which can be transmitted by sexual contact, 8 have the greatest incidence of transmitting disease. Four are curable (Chlamydia, Gonorrhea, Syphilis and Trichomoniasis) and 4 are incurable at present (Hepatitis B, Herpes simplex virus (HSV), Human immunodeficiency virus (HIV) and Human papillomavirus (HPV)). Sexually transmitted infections (STIs) are important as they can cause: Increased rates of acquisition of other STIs (ie HSV and syphilis increase the rate of HIV infection acquisition) Pelvic inflammatory disease and infertility Stillbirth and neonatal death Neonatal morbidity i...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
ConclusionOlder adults had more desire to participate in human clinical GTT trials than younger participants. When recruiting for trials, researchers should develop GTT educational materials that address participant lack of trust in the healthcare system, cultural beliefs, fears related to side effects, and include visual illustrations. Use of such materials will provide adults with SCD the information they need to fully evaluate GTT.
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
Scientists have used a 3D printer to make a scaffold of a soft plastic type material known as a hydrogel. The researchers then loaded this scaffold with the egg sacs known as ovarian follicles from a female mouse and implanted it. The follicles began maturing and released eggs, which were fertilised by natural mating and the mice then went on to give birth to live young. [Laronda et al, Nature Commun, 2017, DOI: 10.1038/ncomms15261]. A similar synthetic ovary might one day be used to treat infertility in women who have had cancer chemotherapy. Chemotherapy causes ovarian failure, essentially destroying a woman’s egg...
Source: David Bradley Sciencebase - Songs, Snaps, Science - Category: Science Authors: Tags: Cancer Science Source Type: blogs
Abstract Tall stature is statistically defined as a height standard deviation score (SDS) above 2 for a given age, sex and population group. The most common cause of tall stature is constitutional (often familial) tall stature. However, underlying endocrine or genetic disorders must be considered as some of them may require specific treatment or management. In constitutional tall stature, healthy children are referred to discuss treatment aiming at reducing adult height. The indications of treatment are rare and usually discussed in girls with extremely tall stature (height SDS>4, corresponding to 185cm in girl...
Source: Annales d'Endocrinologie - Category: Endocrinology Authors: Tags: Ann Endocrinol (Paris) Source Type: research
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