Near ‐infrared photoimmunotherapy targeting EGFR—Shedding new light on glioblastoma treatment

In conclusion, the ZEGFR:03115–IR700DX showed specific uptake in vitro and enabled imaging of EGFR expression in the orthotopic brain tumor model. Moreover, the proof‐of‐concept in vivo PIT study demonstrated therapeutic efficacy of the conjugate in subcutaneous glioma xenografts.

Source: International Journal of Cancer - January 19, 2018 Category: Cancer & Oncology Authors: Thomas A. Burley, Justyna M ączyńska, Anant Shah, Wojciech Szopa, Kevin J. Harrington, Jessica K.R. Boult, Anna Mrozek‐Wilczkiewicz, Maria Vinci, Jeffrey C. Bamber, Wojciech Kaspera, Gabriela Kramer‐Marek Tags: Cancer Therapy and Prevention Source Type: research