Ethical Implications in Vaccine Pharmacotherapy for Treatment and Prevention of Drug of Abuse Dependence

AbstractDifferent immunotherapeutic approaches are in the pipeline for the treatment of drug dependence. “Drug vaccines” aim to induce the immune system to produce antibodies that bind to drugs and prevent them from inducing rewarding effects in the brain. Drugs of abuse currently being tested using these new approaches are opioids, nicotine, cocaine, and methamphetamine. In human clinical trials, “cocaine and nicotine vaccines” have been shown to induce sufficient antibody levels while producing few side effects. Studies in humans, determining how these vaccines interact in combination with their target drug, are underway. However, although vaccines can become a reasonable treatment opti on for drugs of abuse, there are several disadvantages that must be considered. These include i) great individual variability in the formation of antibodies, ii) the lack of protection against a structurally dissimilar drug that produces the same effects as the drug of choice, and iii) the lack of a n effect on the drug desire that may predispose an addict to relapse. In addition, a comprehensive overview of several crucial ethical issues has not yet been widely discussed in order to have not only a biological approach to immunotherapy of addiction. Overall, immunotherapy offers a range of poss ible treatment options: the pharmacological treatment of addiction, the treatment of overdoses, the prevention of toxicity to the brain or the heart, and the protection of the ...
Source: Journal of Bioethical Inquiry - Category: Medical Ethics Source Type: research

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Credit: New York Times article, Jan. 19, 2016. The United States is in the midst of an opioid overdose epidemic. The rates of opioid addiction, babies born addicted to opioids, and overdoses have skyrocketed in the past decade. No population has been hit harder than rural communities. Many of these communities are in states with historically low levels of funding from the National Institutes of Health (NIH). NIGMS’ Institutional Development Award (IDeA) program builds research capacities in these states by supporting basic, clinical, and translational research, as well as faculty development and infrastructure impro...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - Category: Research Authors: Tags: Pharmacology Medicines Opioids Pain Source Type: blogs
By Carmen Arroyo and Emily ThampoeUNITED NATIONS, Jun 29 2018 (IPS)The World Drug Report 2018, launched this week by the United Nations Office on Drugs and Crime (UNODC), highlighted the importance of gender in drug consumption and behaviour, suggesting it is essential to provide different types of health-care and legal solutions. Only one in five women addicts seeks treatment for drug abuse, the president of the International Narcotics Board (INCB) has warned. Credit: UN Photo/D. GairAs Marie Nougier, Head of Research and Communications at the International Drug Policy Consortium (IDPC) told IPS: “There is certainly...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Active Citizens Development & Aid Economy & Trade Global Headlines Health TerraViva United Nations Trade & Investment Source Type: news
“A crisis is a terrible thing to waste,” is a phrase coined by Stanford economist Paul Romer. Politicians are always in search of new crises to address—new fires to put out—with rapid and decisive action. In their passion to appear heroic to their constituents they often act in haste, not ta king the time to develop a deep and nuanced understanding of the issue at hand, insensitive to the notion that their actions might actually exacerbate the crisis.An example of that lack of understanding was made apparent in a  press release by the office of House Majority Whip Steve Scalise (R-LA) on J...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
In response to the current opioid crisis, the National Library of Medicine partnered with Healthy Roads Media to produce a collection of materials that teach people about opioids and opioid misuse. The collection of Opioid Misuse and Addiction Resources has 22 easy-to-read handouts, videos, and audio recordings in English and Spanish. Opioids Basics Pain Prescription opioid medicines Opioid pain medication management What you should know if your child is prescribed opioids for pain Getting rid of unused opioids Opioid addiction What is drug addiction? Why do people take drugs? Opioids and the brain Why do some people be...
Source: NN/LM Middle Atlantic Region Blog - Category: Databases & Libraries Authors: Tags: Consumer Health Health Professionals Public Health Source Type: news
This report describes the expansion of SSPs in Kentucky, North Carolina, and West Virginia during 2013-August 1, 2017. State-level data on the number of SSPs, client visits, and services offered were collected by each state through surveys of SSPs and aggregated in a standard format for this report. In 2013, one SSP operated in a free clinic in West Virginia, and SSPs were illegal in Kentucky and North Carolina; by August 2017, SSPs had been legalized in Kentucky and North Carolina, and 53 SSPs operated in the three states. In many cases, SSPs provide integrated services to address hepatitis and human immunodeficiency viru...
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
The US Surgeon General, Dr. Jerome Adams, recently released an advisory on naloxone and opioid overdose. In his advisory, Dr. Adams writes: For patients currently taking high doses of opioids as prescribed for pain, individuals misusing prescription opioids, individuals using illicit opioids such as heroin or fentanyl, health care practitioners, family and friends of people who have an opioid use disorder, and community members who come into contact with people at risk for opioid overdose, knowing how to use naloxone and keeping it within reach can save a life. This was the first surgeon general advisory issued in 13 years...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Addiction Health Source Type: blogs
April 2-8 marks ‚ÄčNational Public Health Week (NPHW). Each day is marked with a specific public health theme:Monday, April 2: Behavioral HealthAdvocate for and promote well-beingFocus on and advocate for improved access to mental and behavioral health services. Use education and training to de-stigmatize mental health diagnoses and encourage people experiencing mental illness to seek treatment. Coverage for mental health services must be on par with physical health services in all health insurance coverage.Tuesday, April 3: Communicable DiseasesLearn about ways to prevent disease transmissionWash your hands. Know your HIV...
Source: Medicine and Technology by Dr. Joseph Kim - Category: Information Technology Source Type: blogs
Conclusion Using the three Cs of risk management strategies—collecting information, communicating, and carefully documenting—when prescribing controlled substances supports quality patient care and can decrease the risk of improper prescribing allegations. Appendix 1. Prescribing Controlled Substances: Informed Consent Some, but not all states have promulgated various requirements and recommendations for components of an informed consent discussion when prescribing controlled substances.  The following is a compilation of current individual state requirements and recommendations for informed consent. ...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Risk Management Source Type: research
See something of interest? Please share our postings with colleagues in your institutions! Spotlight All NNLM MAR funding opportunities are currently closed. In February, we will announce opportunities to apply for projects starting May 15, 2018. Now is the perfect time to start meeting with potential partners and consulting with NNLM MAR staff on health information outreach ideas. Contact us to set up a consultation. It’s Not Too Late to Participate in National Drug and Alcohol Facts Week 2018! Learn more about free materials, activities, and opportunities for your school, public library, or community organization t...
Source: NN/LM Middle Atlantic Region Blog - Category: Databases & Libraries Authors: Tags: Weekly Postings Source Type: news
When I read the Washington Post article about the CDC censoring seven words last Friday night, my mind immediately jumped to the youth I take care of every day in my Baltimore clinic.  It felt like a direct attack on the very patients I became a doctor to treat: the transgender young person initiating gender-affirming hormone treatment; the young woman seeking inpatient addiction treatment for the first time after watching her best friend die by overdose; the young man who stopped antidepressants after losing his health insurance, only to find solace in the mind-numbing blur of heroin.  These diverse, vulnerable,...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Policy Emergency Medicine Public Health & Source Type: blogs
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