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Ethical Implications in Vaccine Pharmacotherapy for Treatment and Prevention of Drug of Abuse Dependence

AbstractDifferent immunotherapeutic approaches are in the pipeline for the treatment of drug dependence. “Drug vaccines” aim to induce the immune system to produce antibodies that bind to drugs and prevent them from inducing rewarding effects in the brain. Drugs of abuse currently being tested using these new approaches are opioids, nicotine, cocaine, and methamphetamine. In human clinical trials, “cocaine and nicotine vaccines” have been shown to induce sufficient antibody levels while producing few side effects. Studies in humans, determining how these vaccines interact in combination with their target drug, are underway. However, although vaccines can become a reasonable treatment opti on for drugs of abuse, there are several disadvantages that must be considered. These include i) great individual variability in the formation of antibodies, ii) the lack of protection against a structurally dissimilar drug that produces the same effects as the drug of choice, and iii) the lack of a n effect on the drug desire that may predispose an addict to relapse. In addition, a comprehensive overview of several crucial ethical issues has not yet been widely discussed in order to have not only a biological approach to immunotherapy of addiction. Overall, immunotherapy offers a range of poss ible treatment options: the pharmacological treatment of addiction, the treatment of overdoses, the prevention of toxicity to the brain or the heart, and the protection of the ...
Source: Journal of Bioethical Inquiry - Category: Medical Ethics Source Type: research

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See something of interest? Please share our postings with colleagues in your institutions! Spotlight All NNLM MAR funding opportunities are currently closed. In February, we will announce opportunities to apply for projects starting May 15, 2018. Now is the perfect time to start meeting with potential partners and consulting with NNLM MAR staff on health information outreach ideas. Contact us to set up a consultation. It’s Not Too Late to Participate in National Drug and Alcohol Facts Week 2018! Learn more about free materials, activities, and opportunities for your school, public library, or community organization t...
Source: NN/LM Middle Atlantic Region Blog - Category: Databases & Libraries Authors: Tags: Weekly Postings Source Type: news
When I read the Washington Post article about the CDC censoring seven words last Friday night, my mind immediately jumped to the youth I take care of every day in my Baltimore clinic.  It felt like a direct attack on the very patients I became a doctor to treat: the transgender young person initiating gender-affirming hormone treatment; the young woman seeking inpatient addiction treatment for the first time after watching her best friend die by overdose; the young man who stopped antidepressants after losing his health insurance, only to find solace in the mind-numbing blur of heroin.  These diverse, vulnerable,...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Policy Emergency Medicine Public Health & Source Type: blogs
More than 78 American's die daily from an opioid related overdose; a 500% increase since 2000. The epidemic has effected the Appalachian region of the United States particularly hard. To combat the crisis, ACOG and other leading societies recommend the use of Medication Assisted Treatment (MAT) in the form of methadone or more recently buprenorphine for all pregnant women with opioid addiction. Despite the acceptance of MAT as a standard of care, opioid related maternal and neonatal morbidity rates continue to rise.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Poster Session V Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Welcome to the 306th LITFL Review! Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chunk of FOAM. The Most Fair Dinkum Ripper Beauts of the Week RebelEM unleashes his top 10 pearls from ACEP17 [LP] EPMonthly published an ER acco...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: LITFL review #FOAMped #FOAMresus #FOAMsim #FOAMus #meded FOAMcc FOAMed LITFL R/V Source Type: blogs
The U.S. Department of Health and Human Services (HHS) has awarded $144.1 million in grants to prevent and treat opioid addiction. These grants will be administered by the Substance Abuse and Mental Health Services Administration (SAMHSA) through six grant programs:First Responders, theState Pilot Grant for Treatment of Pregnant and Postpartum Women,Building Communities of Recovery,Improving Access to Overdose Treatment,Targeted Capacity Expansion: Medication Assisted Treatment (MAT), and theServices Grant Program for Residential Treatment for Pregnant and Postpartum Women.
Source: News stories via the Rural Assistance Center - Category: Rural Health Source Type: news
In response to the growing heroin epidemic in the United States, the National Library of Medicine’s Specialized Information Services has created a portal to provide resources and information on prescribing, overdose, medication-assisted treatment, and recovery. According to the American Society of Addiction Medicine, addiction is defined as: “A primary, chronic disease of brain reward, motivation, memory and related circuitry. Dysfunction in these circuits leads to characteristic biological, psychological, social and spiritual manifestations. This is reflected in an individual pathologically pursuing reward an...
Source: Dragonfly - Category: Databases & Libraries Authors: Tags: News from NLM Public Health Source Type: news
As wepreviously discussed, the fierce debate about whether to revise, or " repeal and replace Obamacare " , more formally, the Affordable Care Act, continues in the US.  The legislators in the US House of Representatives, and then the US Senate who have written " repeal and replace " bills have done so without any obvious input from health care professionals, health care policy experts, or patients, much less legislators from the opposition party, and so far have impeded any consideration of these bills by legislative committees.  Nonetheless, many of the politicians involved in the debates, a...
Source: Health Care Renewal - Category: Health Management Tags: health care reform ill-informed management logical fallacies Source Type: blogs
See something of interest? Please share our postings with colleagues in your institutions! Spotlight Join the Conversation! Upcoming twitter chats for Minority Mental Health Month have been posted by the Office of Minority Health. Did you know? The National Library of Medicine offers a guide to web resources on Opiate Addiction and Treatment. It includes links to trustworthy resources on topics such as understanding addiction, opioid overdose, medications to treat opioid addiction, opioid prescribing, and pregnancy/neonatal abstinence syndrome. Explore the Portal today! Grades 9-12! The WOOB Files: Global Warming, is the ...
Source: NN/LM Middle Atlantic Region Blog - Category: Databases & Libraries Authors: Tags: Weekly Postings Source Type: news
Conclusion and Recommendations More intervention-based clinical trials are needed to provide a strong alternative candidate therapy for management of opiate use disorder. Buprenorphine, although a promising candidate, should be researched more regarding treatment retention and patient satisfaction before any conclusions can be made regarding its standard use for opiate substitution maintenance treatment of pregnant patients with opiate use disorder. Heroin-assisted treatment still cannot be considered in opiate addicts refractory to MMT; more data should be collected regarding efficacy in larger participant populations un...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue General Review buphernorphin heroin methadone opiate opiate addiction treatment withdrawal Source Type: research
Conclusion. A review of the literature suggests that there are adequate data supporting the efficacy and general safety of the low-dose use of trazodone for the treatment of insomnia. keywords: insomnia, hypnotics, treatment, trazodone, sedative Keywords: insomnia, hypnotics, treatment, trazodone, sedative Innov Clin Neurosci. 2017;14(9–10):24–34 Introduction Insomnia is characterized by difficulty falling asleep, difficulty staying asleep, or waking too early1 and is associated with significant impairments in daytime activities, which might occur despite adequate opportunities for sleep.2–6 Primary insom...
Source: Innovations in Clinical Neuroscience - Category: Neuroscience Authors: Tags: Current Issue Review hypnotics insomnia sedative trazodone treatment Source Type: research
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