Early radiotherapy linked to better response after thyroidectomy

Research inClinical Endocrinology suggests that adults with differentiated thyroid cancer, who undergo thyroidectomy and start radioiodine therapy within the first three months after surgery, have better outcomes.Healio
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Conclusion RIT in postthyroidectomy setting can be successfully performed within 90 days after CCT. Further research is needed to confirm our findings.
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Authors: van Velsen EFS, Visser WE, van den Berg S, Kam BLR, van Ginhoven TM, Massolt ET, Peeters RP Abstract Background Although international guidelines have become more conservative on the use of radioactive iodine (RAI) therapy, it is still one of the cornerstones of the treatment of patients with advanced differentiated thyroid cancer (DTC). As a large proportion of females diagnosed with DTC is in their reproductive years, knowledge about the effect of RAI on their gonadal and reproductive function is important. Earlier studies evaluating Anti-Müllerian hormone (AMH) as a representative of ovarian reserv...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
AbstractObjectiveThe efficacy of low-dose radioiodine therapy (RIT) for intermediate-risk or high-risk differentiated thyroid cancer (DTC) patients is controversial. Because of the country's shortage of medical facilities for RIT, 1110-MBq RIT for higher risk DTC patients has been performed on an outpatient basis since 2010 in Japan. Herein, we addressed this issue and attempted to determine prognostic factors for the prediction of RIT outcomes.MethodsWe retrospectively analyzed the cases of 119 patients with papillary thyroid cancer who underwent their first RIT with 1110  MBq radioactive iodine (RAI) following a tot...
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research
Conclusions: We conclude, if brain metastases show avid radioiodine uptake, RAI therapy should be offered before EBRT or surgery.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Therapy Concepts I: Endocrinology Source Type: research
Conclusions: Radioiodine therapy has very good remnant ablation rates and good successful therapy rates in lymph nodal metastasis and moderate therapy success rates in lung metastasis and stabilization of the disease in skeletal metastasis.Risk stratification is well established to estimate recurrence/persistence of disease. Our study further reinforces that each patient should undergo initial risk stratification and dynamic risk stratification to improve outcome in thyroid cancer patients.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrinology (Clinical Therapy) Posters Source Type: research
Conclusions: Serum level of thyroglobulin reflects the thyroid tissue burden in the body, hence can be used successfully to evaluate the disease burden at presentation, monitor the recurrences and progression of disease before and after radioioiodine therapy in differentiated thyroid cancer.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Endocrinology (Clinical Therapy) Posters Source Type: research
509Objectives: Elevated serum thyroglobulin (S.Tg) with negative anti-thyroglobulin antibody titre or a rising serum anti-thyroglobulin (S.ATg) titre is known to indicate biochemical disease in patients with differentiated thyroid cancer (DTC), post-surgery. However, histopathologic examination of the surgical specimen often shows foci of lymphocytic thyroiditis synchronous with the primary DTC. Whether this has implications on the serum titres of S. Tg and S. ATg merits further exploration. The present study was conducted to correlate baseline elevated S. ATg in patients of DTC with histopathology of total thyroidectomy s...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Thyroid and Para-Thyroid Source Type: research
Conclusion: This case of thyroid bed PG supports the idea that PG reflects a cutaneous phenotype encompassed in the spectrum of systemic neutrophilic diseases. Endocrinologists should be aware that thyroid bed PG involvement is an albeit rare differential diagnosis to consider in patients who had undergone thyroid surgery, especially with a history of PG. Introduction Papillary thyroid carcinoma (PTC), the main variant of differentiated thyroid carcinoma (DTC), is the most common thyroid cancer, accounting for 70–80% of all thyroid carcinomas and occurring predominantly in women, generally with a good prognos...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
CONCLUSIONS: PTC in SO still remains a diagnostic and therapeutic challenge. Immunostaining for CK7, CK19, p63 and Tg might be helpful in histopathological diagnosis. The decision on the need of total thyroidectomy and radioiodine therapy should be made individually. However, thyroid remnant ablation increases the sensitivity and specificity of follow-up testing using serum Tg level as a tumour marker. PMID: 30924920 [PubMed - as supplied by publisher]
Source: Folia Histochemica et Cytobiologica - Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research
A 68-year-old woman who underwent a thyroidectomy for bilateral goiter 20 years ago was referred to our department. The examination revealed a newly occurred thyroid nodule in the right central lobe. Unexpectedly the 99mTc-pertechnetate scan revealed several extrathyroidal foci right-sided supraclavicular, beside a cold thyroid nodule in the right lower lobe. Consecutive surgery and histology confirmed the suspected diagnosis of follicular thyroid cancer with multiple bone metastases. Whole-body scintigraphy performed after the following radioiodine therapy indicated disseminated osseous metastases.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
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