Issue Cover (February 2018)

Front cover: The expression of p75 neurotrophin receptor is elevated in the brain of Alzheimer’s disease patients, suggesting its involvement in this disease. We propose a novel mechanism by which amyloid beta (Aβ) through p75 receptor contributes to a vicious cycle of amyloidogenesis. We found that Aβ can enhance amyloid precursor protein (APP) and beta‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) phosphorylation, and their association and inclusion in endosomes through a p75‐dependent mechanism, leading to further Aβ generation. Cortical neurons were isolated from mouse expressing p75 at early development (P0). The neurons were then cultured on coverslips and stained with rabbit anti‐APP (6687) (Alexa‐Fluor 488; green) and mouse anti‐BACE1 (MAB931) (Cy3; red) at DIV4. Nuclei are stained with DAPI (Blue). The APP/BACE1 colocalization (yellow) was measured in neuronal soma and dendrites. Read the full article ‘p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis’ by K. Saadipour, N. B. Mañucat‐Tan, Y. Lim, D. J. Keating, K. S. Smith, J.‐h. Zhong, H. Liao, L. Bobrovskaya, Y.‐J. Wang, M. V. Chao and X.‐F. Zhou (J. Neurochem. 2018, vol. 144(3), pp. 302–317) on doi: 10.1111/jnc.14206
Source: Journal of Neurochemistry - Category: Neuroscience Tags: Issue Cover Source Type: research