Regional pattern of microgliosis in sporadic Creutzfeldt ‐Jakob disease in relation to phenotypic variants and disease progression

ConclusionsMicroglial activation is an early event in sCJD pathogenesis and is strongly influenced by prion strain, PRNP codon 129 genotype and disease duration. Microglial lesion profiling, by highlighting strain‐specific properties of prions, contributes to prion strain characterization and classification of human prion diseases, and represents a valid support to molecular and histopathologic typing.This article is protected by copyright. All rights reserved.
Source: Neuropathology and Applied Neurobiology - Category: Neurology Authors: Tags: Original Article Source Type: research