How did a deadly tropical fungus get to the temperate environs of the Pacific Northwest?

(The Translational Genomics Research Institute) In what is being described as 'The Teddy Roosevelt effect,' a deadly fungus in the Pacific Northwest may have arrived from Brazil via the Panama Canal, according to a new study led by the Translational Genomics Research Institute (TGen). Cryptococcus gattii -- which until a 1999 outbreak in British Columbia's Vancouver Island was considered primarily a tropical fungus -- can cause deadly lung and brain infections in both people and animals.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Abstract DNA repair pathways are closely associated with the maintenance of genomic integrity, disease outbreak, and the development of therapeutics. Owing to these significances, novel analytical methods for enzymes that are involved in the DNA repair pathways have been actively investigated. This review focuses on discussions on nucleic acid-based methods, especially those based on the fluorescence, for the determination of DNA repair enzymes. Furthermore, this review not only provides meaningful insights in creating ingenious fluorescent detection methods but it also suggests future directions that will be foll...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Climate change is in the news more and more, and the projections from virtually all of the world’s climate scientists are becoming increasingly dire. Almost daily, we are confronted with images of extreme weather patterns, disease outbreaks, and the loss of certain species. It is almost biblical in proportion. Most poignant, to me, are the distressing images of starving, displaced polar bears whose icy habitats are melting away. Many of the things that we can do to prevent or slow climate change are intuitive, difficult as they may be to put into practice: conserve energy, drive less, elect politicians that are dedic...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Environmental health Food as medicine Source Type: blogs
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Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
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Source: - Health - Category: Consumer Health News Source Type: news
Yersinia pestis causes bubonic, pneumonic, and septicemic plague. Although no longer responsible for pandemic outbreaks, pneumonic plague continues to be a challenge for medical treatment and has been classified as a reemerging disease in some parts of the world. In the early stage of infection, inflammatory responses are believed to be suppressed by Y. pestis virulence factors in order to prevent clearance, while later, the hyperactivation of inflammation contributes to the progression of disease. In this work, we sought to identify the host factors that mediate this process and studied the role of the Toll/interleukin 1 ...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Host Response and Inflammation Source Type: research
In this study, we found that an E. coli O26:H11 strain that produces both Stx1a and Stx2a was virulent in streptomycin- and ciprofloxacin-treated mice and that mice were protected by administration of an anti-Stx2 antibody. However, we discovered that in the absence of ciprofloxacin, neutralization of Stx1a enhanced the virulence of the strain, a result that corroborated our previous finding that Stx1a reduces the toxicity of Stx2a by the oral route. We further found that intraperitoneal administration of the purified Stx1a B subunit delayed the mean time to death of mice intoxicated with Stx2a and reduced the cytotoxic ef...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Molecular Pathogenesis Source Type: research
Effects of dengue immunity on Zika virus infection, Published online: 25 March 2019; doi:10.1038/d41586-019-00868-6The factors that contributed to the explosive nature of the 2015 Zika outbreak in the Americas are not well understood. A new analysis explores the link between prior dengue virus exposure and Zika virus infection.
Source: Nature AOP - Category: Research Authors: Source Type: research
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Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
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Source: Emerging Infectious Diseases - Category: Infectious Diseases Authors: Tags: Emerg Infect Dis Source Type: research
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