Cardioprotection of dapagliflozin and vildagliptin in rats with cardiac ischemia-reperfusion injury

In conclusion, dapagliflozin has a more pronounced effect than vildagliptin in obese insulin-resistant rats for the improvement of LV function. In rats with cardiac I/R injury, although dapagliflozin had a greater efficacy on cardioprotection than vildagliptin, the combined therapy exerted the highest cardioprotective effects potentially by reducing mitochondrial fission.

Source: Journal of Endocrinology - January 18, 2018 Category: Endocrinology Authors: Tanajak, P., Sa-nguanmoo, P., Sivasinprasasn, S., Thummasorn, S., Siri-Angkul, N., Chattipakorn, S. C., Chattipakorn, N. Tags: Research Source Type: research