Specific IgE to gelatin as a cause of anaphylaxis to zoster vaccine

Reading the recent letter from Stone et  al1 reminded us of a subject from our previous galactose-α-1,3-galactose (alpha-gal) study. Indeed, she may well be the same 76-year-old lady found in the letter (Table E1) who was reported as negative to alpha-gal. Her first reaction to meat started 45 minutes after eating barbecue, only a few months following her recovery from Lyme disease.2,3 Since then she has had multiple reactions of varying severity, some of which started less than 1 hour after ingestion of red meat.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research

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Authors: Nakata J, Nakajima H, Hayashibara H, Imafuku K, Morimoto S, Fujiki F, Motooka D, Okuzaki D, Hasegawa K, Hosen N, Tsuboi A, Oka Y, Kumanogoh A, Oji Y, Sugiyama H Abstract In immunotherapy by cancer antigen-derived peptide vaccine, vaccination of cytotoxic T lymphocyte (CTL) peptide alone is common, while it remains unclear whether the addition of helper peptide vaccine to the CTL peptide vaccine is of great advantage for the enhancement of tumor immunity. In the present study, combination vaccine of Wilms' tumor gene 1(WT1) protein-derived CTL and helper peptides induced the strong infiltration of WT1-speci...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
This study evaluated the safety, immune responses and clinical outcomes of patients who received a CHP-MAGE-A4 vaccine. Twenty-two patients with advanced or metastatic cancer were enrolled, and were subcutaneously vaccinated with either 100 μg or 300 μg of CHP-MAGE-A4. Seven and 15 patients, respectively, were repeatedly vaccinated with 100 μg or 300 μg of CHP-MAGE-A4; patients in both groups received a median of 7 doses. No serious adverse events related to the vaccine were observed. Of 7 patients receiving the 100 μg dose, 2 (29%) showed immune responses, compared with 3 of the 14 (21%) patients who receiv...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Conclusion: The expanded MOPA will be useful for evaluation of the immunogenicity of PPV23 and future conjugate vaccine formulations. PMID: 30546285 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
This study recommends an in vivo assessment for the most promising peptides especially FFKEHGVPL. PMID: 30542244 [PubMed]
Source: Bioinformatics and Biology Insights - Category: Bioinformatics Authors: Tags: Bioinform Biol Insights Source Type: research
Green was responding to a question from a mother who has a child with autism asking about Medicaid spending cuts
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
[AN UPDATE ON DIAGNOSIS AND MANAGEMENT OF DRUG ALLERGY]. Arerugi. 2018;67(10):1399-1404 Authors: Aihara M PMID: 30541975 [PubMed - in process]
Source: Arerugi - Category: Allergy & Immunology Authors: Tags: Arerugi Source Type: research
[FOOD ALLERGY]. Arerugi. 2018;67(10):1368-1378 Authors: Yanagida N PMID: 30541971 [PubMed - in process]
Source: Arerugi - Category: Allergy & Immunology Authors: Tags: Arerugi Source Type: research
In older mice and humans, the immune system becomes dysfunctional. It is overactive, producing chronic inflammation that leads to harmful cellular behavior throughout the body, but at the same time it is much less capable when it comes to destroying pathogens and errant cells. In today's open access research, scientists investigate the incapacity of naive T cells in older mice. This population of T cells is necessary for a strong immune response, but their numbers decline due to the involution of the thymus. T cells begin life as thymocytes in the bone marrow, and then migrate to the thymus where they mature into T cells o...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Reading the recent letter from Stone et  al1 reminded us of a subject from our previous galactose-α-1,3-galactose (alpha-gal) study. Indeed, she may well be the same 76-year-old lady found in the letter (Table E1) who was reported as negative to alpha-gal. Her first reaction to meat started 45 minutes after eating barbecue, only a few months following her recovery from Lyme disease.2,3 Since then she has had multiple reactions of varying severity, some of which started less than 1 hour after ingestion of red meat.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research
​How could a Lyme disease lookalike rash and anaphylaxis to meat have anything in common? As I found out recently, they do. They both have a common vector, the Lone Star Tick, which is also known by its formal name, Amblyomma americanum, and is found predominately in the East, Southeast, and Southwest. It is an aggressive tick that loves humans.In fact, all three growth stages (adult, nymph, and larva) are known to feed on humans. Besides the common signs of irritation that often accompany a tick bite, a rash similar to the rash of Lyme disease has been commonly described. This "bull's-eye" rash is often accomp...
Source: M2E Too! Mellick's Multimedia EduBlog - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
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