Supplementation with Curcuma longa reverses neurotoxic and behavioral damage in models of Alzheimer's disease: A systematic review.

CONCLUSION: The administration of curcumin in experimental models seems to be a promising approach in AD, even though it is suggested that additional studies must be conducted using distinct doses and through other routes of administration. PMID: 29338678 [PubMed - as supplied by publisher]
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research

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DEMENTIA is not a disease but it is a collection of symptoms that result from the major damage in the brain caused by diseases such as Alzheimer ’s, and the severity of dementia is different for each person. What are the five major symptoms to look out for in order to get help with early detection of dementia?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
The FDA has issued warning letters and online advisory letters to a number of domestic and foreign companies illegally selling unapproved new drug and misbranded drug products that claim to prevent, treat, mitigate or cure Alzheimer ’s disease.
Source: FDA Center for Drug Evaluation and Research - What's New - Category: Drugs & Pharmacology Authors: Source Type: news
ConclusionMethods:The two alleles of ApoE (E3 and E4) differ in one nucleotide. Based on this single-nucleotide polymorphism (SNP), we designed a novel “clustered regularly interspaced short palindromic repeats” (CRISPR) based system that specifically recognizes, binds and targets the ApoE4 allele for knockout by using the VRER CRISPR associated protein 9 (Cas9) variant.Results and conclusionApplication of this approach in mice astrocytes expressing the human ApoE3 or ApoE4 resulted in a significant decrease of ApoE4 protein levels (-70%) without any significant changes in ApoE3 levels. The cell-culture experim...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionWe used gold nanoparticles loaded exosomes for in-vivo neuroimaging and present specific migration and homing to various brain pathologies including stroke, Parkinson's, Alzheimer's, Autism and healthy brains as a control. By this method, we visualized the migration and homing abilities of exosomes in long-term follow-up ad report that in pathological areas they home for more than 96 hours while in healthy brains they are being evacuated within 24 hours. Furthermore, we show that MSC-exo uses chemotaxis signaling to target the inflammatory areas in the brain.
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionWe used the CRISPR-Cas9 system to knock down the small subunit of the calpain protein in mice astrocytes expressing either the human ApoE3 or ApoE4 alleles. We then investigated, the resulting effects of the Calpain knock down on the expression of autophagy-related proteins and on the uptake of fluorescent Aβ.We found that the levels of mitofusin1, a protein responsible for the fusion and integrity of the mitochondria and p62 a protein that undergoes degradation during autophagy, are higher in the ApoE4 compared to ApoE3. However, in astrocytes treated with CRISPR-Cas9, which reduced the levels calpain by 75...
Source: Cytotherapy - Category: Cytology Source Type: research
ConclusionFor that purpose, we subjected 5XFAD mice to myeloablative irradiation and bone marrow-repopulation from MPO Knock-out (KO) mice to form 'MPO KO-5XFAD' mice. MPO KO-5XFAD mice exhibited improvement in their risk assessment behavior, as measured by the 'Elevated plus maze/ test and the 'Open field' test, when compared to 5XFAD mice transplanted with WT cells (termed 'WT-5XFAD'). Remarkably, MPO KO-5XFAD mice also showed improved spatial recognition and learning, as was evident in the 'Y-maze' test, the 'Morris water maze' test and by 'Contextual fear conditioning' test. Hippocampal RNA expression analysis by QPCR ...
Source: Cytotherapy - Category: Cytology Source Type: research
Publication date: Available online 23 May 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Ghada Omar Tuffaha, Mamon M. Hatmal, Mutasem O. TahaAbstractThe kinase c-Jun N-terminal Kinase 3 (JNK3) plays an important role in neurodegenerative diseases. JNK3 inhibitors have shown promising results in treating Alzheimer's and Parkinson's diseases. This prompted us to model this interesting target via three established structure-based computational workflows; namely, docking-based Comparative Intermolecular Contacts Analysis (db-CICA), pharmacophore modeling via molecular-dynamics based Ligand-Receptor Contact A...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
Contributors : Akinori Miyashita ; Hiroyuki Hatsuta ; Masataka Kikuchi ; Akihiro Nakaya ; Yuko Saito ; Tamao Tsukie ; Norikazu Hara ; Soichi Ogishima ; Nobutaka Kitamura ; Kohei Akazawa ; Akiyoshi Kakita ; Hitoshi Takahashi ; Shigeo Murayama ; Yasuo Ihara ; Takeshi Ikeuchi ; Ryozo KuwanoSeries Type : Expression profiling by arrayOrganism :Transcriptome analysis of post-mortem brain tissue specimens from three brain regions (BRs), entorinal, temporal and frontal cortices, of 71 Japanese brain-donor subjects to identify genes relevant to the expansion of neurofibrillary tangles. In total, 213 brain tissue specimens (= 71 sub...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Source Type: research
(University of Illinois at Chicago) Researchers examining post-mortem brain tissue from people ages 79 to 99 found that new neurons continue to form well into old age. The study provides evidence that this occurs even in people with cognitive impairment and Alzheimer's disease, although neurogenesis is significantly reduced in these people compared to older adults with normal cognitive functioning.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Dementia is a common disorder in older adults where the major subtypes include Alzheimer ’s disease and vascular dementia [1]. Traditional tests designed to diagnose neurodegenerative disorders are often delayed in detecting abnormalities in cognitive decline in the earliest stages of the disease [2]. Hence, there is a need for robust pragmatic and objective tools to aid clinical deci sions.
Source: Maturitas - Category: Primary Care Authors: Source Type: research
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