Supplementation with Curcuma longa reverses neurotoxic and behavioral damage in models of Alzheimer's disease: A systematic review.

CONCLUSION: The administration of curcumin in experimental models seems to be a promising approach in AD, even though it is suggested that additional studies must be conducted using distinct doses and through other routes of administration. PMID: 29338678 [PubMed - as supplied by publisher]
Source: Current Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Neuropharmacol Source Type: research

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CONCLUSIONS Silencing ACAT1 attenuates Aβ₂₅₋₃₅-induced cytotoxicity and cell apoptosis in SH-SY5Y cells, which may due to the synergistic effect of ACAT1 and COX2 through PKC/ERK pathways. PMID: 30541014 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Abstract PMID: 30539900 [PubMed - in process]
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
A diffusion-tensor MR image (DTI-MRI) of a mouse kidney described as "stunning"...Read more on AuntMinnie.comRelated Reading: DTI-MRI offers window into Alzheimer's risk DTI-MRI ties lack of fitness to cognitive decline DTI-MRI poses new cause for schizophrenia DTI-MRI links key brain regions to cognitive disorders DTI-MRI unlocks mysteries of insomnia
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Once dementia is part of the family, it will be part of the holidays. The person with dementia will have good days and bad days and will change as the disease progresses. One thing we can count on, though, is that a loved one with dementia will need special consideration. How does a caregiver realistically cope with the holidays? View the slideshow on HealthCentral for tips on celebrating Christmas when someone lives with dementia:   MedicareFAQ – Medicare Resource Center Support a caregiver or jump-start discussion in support groups with real stories - for bulk orders of Minding Our Elders e-mail Carol&nbs...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Sticky proteins can be transferred between people Related items fromOnMedica Anticholinergic drugs may be linked to increased risk of dementia Risk of Alzheimer ’s lower in people with gout Don ’t delay young children’s surgery for fear of GA harms Genes identified involved in age-related brain deterioration Low vitamin D levels linked to faster cognitive decline
Source: OnMedica Latest News - Category: UK Health Source Type: news
Scientists test spray in patients with motor neurone disease Related items fromOnMedica MHRA tightens licence restrictions on valproate for women New evidence on benzodiazepine link to Alzheimer ’s Debate goes on over valproate in pregnancy Cannabis compound may help curb frequency of epileptic seizures Government to review medicinal use of cannabis
Source: OnMedica Latest News - Category: UK Health Source Type: news
Alzheimer ’s disease (AD) affects nearly 50 million people worldwide, and currently no disease-modifying treatment is available. With continuous failure of anti-amyloid-beta- or tau-based therapies, identification of new targets has become an urgent necessity for AD prevention and therapy. Recently, convent ional genetic approaches and computational strategies have converged on immune-inflammatory pathways as key events in the pathogenesis of AD. A number of genes have been highly linked to the onset and development of late-onset sporadic AD, the most common form of AD. Strikingly, most of these genes are involved in...
Source: Gerontology - Category: Geriatrics Source Type: research
Background: Bright light treatment is a therapeutic intervention mainly used to treat sleep and circadian disturbances in Alzheimer ’s disease (AD) patients. Recently, a handful of studies also focused on the effect on cognition and behavior. Conflicting findings are reported in the literature, and no definite conclusions have been drawn about its specific therapeutic effect.Summary: The aim of this review is to provide a critical evaluation of available evidence in this field, highlighting the specific characteristics of effective bright light treatment. Eligible studies were required to assess at least one of the f...
Source: Dementia and Geriatric Cognitive Disorders - Category: Geriatrics Source Type: research
The objective of this study was to examine whether reduced awareness of memory deficits in individuals with dementia is associated with more frequent need for Medicare home health care services. METHODS: Cross-sectional analyses were conducted in a multicenter, clinic-based cohort. In total, 192 participants diagnosed with dementia and their informants were independently asked whether or not the participant demonstrated cognitive symptoms of dementia related to memory and word-finding. Participant self-awareness was measured as the discrepancy between participant and caregiver report of these symptoms. Annual Medicare ...
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Authors: Cuenca L, Gil-Martinez AL, Cano-Fernandez L, Sanchez-Rodrigo C, Estrada C, Fernandez-Villalba E, Herrero MT Abstract After Alzheimer's disease, Parkinson's disease (PD) is the second most prevalent and incidental neurodegenerative disorder, affecting more than 2% of the population older than 65 years old. Since it was first described 200 years ago by Dr James Parkinson, great steps have been made in the understanding of the pathology. However, the cause(s) that initiates and perpetuates the neurodegenerative process is (are) still not clear. Thus, early diagnosis is not available, nor are there efficient t...
Source: Histology and Histopathology - Category: Cytology Tags: Histol Histopathol Source Type: research
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