Supplementation with Curcuma longa reverses neurotoxic and behavioral damage in models of Alzheimer's disease: A systematic review.
CONCLUSION: The administration of curcumin in experimental models seems to be a promising approach in AD, even though it is suggested that additional studies must be conducted using distinct doses and through other routes of administration. PMID: 29338678 [PubMed - as supplied by publisher]
Publication date: Available online 15 August 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Angélica Torres-Berrio, Mauricio O. Nava-MesaAbstractCognitive and emotional impairment are a serious consequence of stress exposure and are core features of neurological and psychiatric conditions that involve memory disorders. Indeed, acute and chronic stress are high-risk factors for the onset of posttraumatic stress disorder (PTSD) and Alzheimer’s disease (AD), two devastating brain disorders associated with memory dysfunction. Besides the sympathetic nervous system and the hypo...
CONCLUSIONS In a transgenic mouse model of AD, miR-137 and expression of the CACNA1C gene inhibited the hyperphosphorylation of tau protein. PMID: 30102687 [PubMed - in process]
Conclusions:DORAs offer an additional treatment option for insomnia. More clinical trials are needed to robustly evaluate their safety and effectiveness in several subclasses of individuals with insomnia. Given the published literature, head-to-head comparisons to existing treatment for insomnia are warranted.Citation:Janto K, Prichard JR, Pusalavidyasagar S. An update on dual orexin receptor antagonists and their potential role in insomnia therapeutics.J Clin Sleep Med. 2018;14(8):1399–1408.
Publication date: Available online 14 August 2018Source: NeuroImage: ClinicalAuthor(s): Annegreet van Opbroek, Hakim C. Achterberg, Meike W. Vernooij, M. Arfan Ikram, Marleen de Bruijne, Alzheimer's Disease Neuroimaging InitiativeAbstractMany successful approaches in MR brain segmentation use supervised voxel classification, which requires manually labeled training images that are representative of the test images to segment. However, the performance of such methods often deteriorates if training and test images are acquired with different scanners or scanning parameters, since this leads to differences in feature represen...
Can a chemical that reinforces the connections in our brains prevent the destruction of memories in ageing and Alzheimer ’s? It seems to work in mice
DiscussionBBB breakdown is associated with cognitive decline. Cell adhesion, neutrophil migration, high-density lipoprotein metabolism, and angiogenesis are implicated.
More insight into the eye as a'window into the brain'comes from a study linking glaucoma, age-related macular degeneration, and diabetic retinopathy to a higher risk for Alzheimer's disease.Medscape Medical News
(MedPage Today) -- News and commentary from the world of neurology and neuroscience
NEW GENES that may contribute to Alzheimer's disease have been identified by scientists.
Conditions: Alzheimer Disease; Dementia Intervention: Sponsor: Faroese Hospital System Recruiting