Racial Differences in 21-Gene Recurrence Scores Among Patients With Hormone Receptor-Positive, Node-Negative Breast Cancer.

Racial Differences in 21-Gene Recurrence Scores Among Patients With Hormone Receptor-Positive, Node-Negative Breast Cancer. J Clin Oncol. 2018 Jan 17;:JCO2017745448 Authors: Holowatyj AN, Cote ML, Ruterbusch JJ, Ghanem K, Schwartz AG, Vigneau FD, Gorski DH, Purrington KS Abstract Purpose The 21-gene recurrence score (RS) breast cancer assay is clinically used to quantify risk of 10-year distant recurrence by category (low,
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Oncol Source Type: research

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We report of a case rapid onset systemic sclerosis complicated by acute renal failure and diffuse alveolar hemorrhage in a woman with stage IIB right breast cancer and elevated RNA Polymerase III IgG Ab. To our knowledge, this the first case of a patient with breast cancer associated with systemic sclerosis and pulmonary-renal syndrome.
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Publication date: Available online 16 August 2018Source: Academic RadiologyAuthor(s): Randy C. Miles, Constance Lehman, Erica Warner, Ashley Tuttle, Mansi SaksenaRationale and ObjectivesTo determine awareness and knowledge of breast density and breast density legislation among women receiving routine mammography following passage of Massachusetts breast density legislation.Materials and MethodsA survey assessing breast density awareness and knowledge was administered to all women receiving screening mammography over two separate 1-week periods at an academic medical center following implementation of mandatory breast densi...
Source: Academic Radiology - Category: Radiology Source Type: research
This study identified chemotherapeutic agents that up-regulate programmed cell death ligand-1 (PD-L1) and galectin-9 (Gal-9) in breast cancer cells. Immunohistochemical (IHC) staining was used to evaluate changes in PD-L1 and Gal-9 expression in the tumor tissue of triple-negative breast cancer (TNBC) patients who received anthracycline- and taxane-based neoadjuvant chemotherapy. To determine whether PD-L1 and Gal-9 expression changes were attributable directly to chemotherapeutics, MDA-MB-231 cells and HS578 T cells were treated with different concentrations of anthracycline and taxane. Expression levels of PD-L1 a...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
We report three cases of postmenopausal women with hormone receptor-positive breast cancer, who experienced tendinopathy or muscle tendon rupture under antihormonal treatment with letrozole. All of the three women were in the adjuvant setting, and the treatment of tendinopathy or tendon rupture consisted of AI discontinuation, initiation of corticosteroids, or surgical treatment. Diagnosis was made via MRI. Furthermore, in our cases, there were no signs of underlying systemic disease, there was no abnormal physical activity preceding the complaints, and there was no use of other drugs beside letrozole. AIs are one of the m...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsBrachytherapy APBI is associated with higher rates of grade 1 fibrosis and seroma than 3D-CRT but lower rates of grade 1 edema and grade 2-3 pain than 3D-CRT. Rates of radiation oncologist-reported “fair” or “poor” cosmetic outcome are higher with brachytherapy. We identified dosimetric parameters that predict reduced risk of adverse cosmetic outcome after brachytherapy-based APBI. Ipsilateral breast recurrence was equivalent for brachytherapy and 3D-CRT.
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Conclusion: We propose a simple gene expression signature of only three RNA species could be employed clinically to predict pCR in TNBC patients receiving NAC.Cell Physiol Biochem 2018;48:2539 –2548
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
In this study, a hierarchical approach (ligand binding to sodium caseinate and then either re-assembling the micellar nanostructures or formation casein nanoparticles) was used to encapsulate two phenolic compounds, including curcumin and quercetin. As determined by spectrofluorometry, the binding stoichiometry of quercetin and curcumin were 0.96 and 0.78, respectively. The average particle size of re-assembled casein micelles (r-CMs) was smaller than that of casein nanoparticles (CNPs). The effect of quercetin loading on increasing the particle size of r-CMs was higher than that of curcumin loading due to the higher bindi...
Source: Food Hydrocolloids - Category: Food Science Source Type: research
Conclusions This narrative review highlights inconsistency in the methods used to collect, process, and report accelerometry data across cancer survivor studies. Accelerometry has potential to add detailed knowledge of the levels and patterns of physical activities and sedentary behaviors across the cancer spectrum. Recommendations are made to improve data processing and reporting methods to maximize the scientific validity of future accelerometer research in this field.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: Epidemiology Source Type: research
Conditions:   Metastatic Breast Cancer;   Positive Hormonal Receptors Intervention:   Other: Quality of life in metastatic BC Sponsor:   Institut Cancerologie de l'Ouest Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Boughdad S, Nioche C, Orlhac F, Jehl L, Champion L, Buvat I Abstract Background: To help interpret measurements in breast tissue and breast tumors from 18F-FDG PET scans, we studied the influence of age in measurements of PET parameters in normal breast tissue and in a breast cancer (BC) population. Results: 522 women were included: 331 pts without history of BC (B-VOI) and 191 patients with BC (T-VOI). In B-VOI, there were significant differences between all age groups for Standardized Uptake Values (SUVs) and for 12 textural indices (TI) whereas histogram-based indices (HBI) did not vary between age ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
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