Proton Therapy Not Better Than IMRT in Lung Cancer Proton Therapy Not Better Than IMRT in Lung Cancer

In a randomized trial comparing the two modalities, proton therapy was not superior in reducing the rate of serious lung toxicityMedscape Medical News
Source: Medscape Radiology Headlines - Category: Radiology Tags: Hematology-Oncology News Source Type: news

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1139Introduction: Thoracic malignancies are among the most common malignancies diagnosed both in the United States and worldwide. Radiation therapy (RT) plays an important role in the treatment of thoracic malignancies. Depending on the primary disease site and tumor stage, RT can be used as monotherapy, or as part of multimodality therapy for curative intent, or for palliative reduction of advanced disease. In fact, more than 50% of all patients with thoracic malignancies will receive RT as part of their multidisciplinary care. 18F-Fluorodeoxyglucose positron emission tomography (PET) is commonly used for initial cancer d...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibit Posters Source Type: research
We report the early clinical outcomes and toxicities of intensity-modulated proton therapy (IMPT) vs. intensity-modulated radiation therapy (IMRT) in patients with locally-advanced NSCLC.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research
We explored spatial dose patterns associated with symptomatic radiation pneumonitis (RP) in patients with non-small-cell lung cancer given either intensity-modulated photon therapy or passive scattering proton therapy. A dose distribution analysis highlighted regional dose differences associated with both RP status and treatment modality, showing that regions spared with protons are complementary to those correlated with RP; these results can be useful for clinical practice and for designing future trials to minimize RP.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Physics Contribution Source Type: research
This article reviews pertinent studies evaluating the use of IMRT and proton therapy in locally advanced NSCLC, and outlines challenges, indications for use, and areas for future research. PMID: 30206493 [PubMed]
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Authors: Molitoris JK, Diwanji T, Snider JW, Mossahebi S, Samanta S, Badiyan SN, Simone CB, Mohindra P Abstract The development of advanced radiation technologies, including intensity-modulated radiation therapy (IMRT), stereotactic body radiation therapy (SBRT) and proton therapy, has resulted in increasingly conformal radiation treatments. Recent evidence for the importance of minimizing dose to normal critical structures including the heart and lungs has led to incorporation of these advanced treatment modalities into radiation therapy (RT) for non-small cell lung cancer (NSCLC). While such technologies have all...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
We compared differences in patterns of locoregional failure, and the influence of adaptive planning on those patterns, in patients who received passive scattering proton therapy (PSPT) versus intensity modulated photon therapy (IMRT) for non-small cell lung cancer.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
We compared differences in patterns of local-regional failure, and the influence of adaptive planning on those patterns, for 212 patients given passively scattered proton therapy (PSPT) or intensity-modulated radiation therapy (IMRT), both with concurrent chemotheapy, for non-small cell lung cancer. No differences in patterns of local, marginal, or regional failure were found between treatment groups, and use of adaptive planning (or not) did not influence failure patterns.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Clinical Investigation Source Type: research
1224Aim:Radeation therapy (RT) is an important component of cancer treatment for both early stage and locally advanced lung cancers. Photon and proton therapies are both utilized for RT but have different physical characteristics. Photon RT actively exposes healthy tissues along the beam path in front of and beyond the tumor to incidental irradiation. However, due to a central-axis depth-dose distribution pattern known as the spread-out Bragg peak (SOBP), proton RT generally has a more optimal dose delivery in comparison to 3D conformal photon therapy and intensity-modulated radiation therapy (IMRT). The SOBP may potential...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibits Source Type: research
Publication date: Available online 6 March 2018 Source:Seminars in Ultrasound, CT and MRI Author(s): Marcelo F Benveniste, Sonia L. Betancourt Cuellar, Daniel Gomez, Girish S. Shroff, Brett W. Carter, Ana Paula A. Benveniste, Edith M. Marom Radiation therapy is an important modality in the treatment of patients with lung cancer. Recent advances in delivering radiotherapy were designed to improve loco-regional tumor control by focusing higher doses on the tumor. More sophisticated techniques in treatment planning include three dimensional conformal radiation therapy (3D CRT), intensity-modulated radiotherapy (IMRT), stereo...
Source: Seminars in Ultrasound, CT and MRI - Category: Radiology Source Type: research
Abstract The goal of this study was to exam the efficacy of current DVH based clinical guidelines draw from photon experience for lung cancer radiation therapy on proton therapy. Comparison proton plans and IMRT plans were generated for 10 lung patients treated in our proton facility. A gEUD based plan evaluation method was developed for plan evaluation. This evaluation method used normal lung gEUD(a) curve in which the model parameter "a" was sampled from the literature reported value. For all patients, the proton plans delivered lower normal lung V5 Gy with similar V20 Gy and similar target coverage. B...
Source: Journal of Applied Clinical Medical Physics - Category: Physics Authors: Tags: J Appl Clin Med Phys Source Type: research
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