Transplantation of in vitro cultured endothelial progenitor cells repairs the blood-brain barrier and improves cognitive function of APP/PS1 transgenic AD mice
To date, the pathogenesis of Alzheimer's disease (AD) remains unclear. It is well-known that excessive deposition of A β in the brain is a crucial part of the pathogenesis of AD. In recent years, the AD neurovascular unit hypothesis has attracted much attention. Impairment of the blood-brain barrier (BBB) leads to abnormal amyloid-β (Aβ) transport, and chronic cerebral hypoperfusion causes Aβ deposition througho ut the onset and progression of AD. Endothelial progenitor cells (EPCs) are the universal cells for repairing blood vessels.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Shishuang Zhang, Yongle Zhi, Fei Li, Shan Huang, Huabin Gao, Zhaoli Han, Xintong Ge, Dai Li, Fanglian Chen, Xiaodong Kong, Ping Lei Source Type: research