Siglec ‐1 inhibits RSV‐induced interferon gamma production by adult T cells in contrast to newborn T cells

In this study, micro‐array data identified the upregulation of sialic acid‐binding immunoglobulin‐type lectin 1 (Siglec‐1) in human RSV‐infected infants. In vitro, RSV increased expression of Siglec‐1 on healthy newborn and adult monocytes. RSV‐induced Siglec‐1 on monocytes inhibited IFN‐γ production by adult CD4+ T cells. In contrast, IFN‐γ production by RSV in newborns was not affected by Siglec‐1. The ligand for Siglec‐1, CD43, is highly expressed on adult CD4+ T cells compared to newborns. Our data show that Siglec‐1 reduces IFN‐γ release by adult T cells possibly by binding to the highly expressed CD43. The Siglec‐1‐dependent inhibition of IFN‐γ in adults and the low expression of CD43 on newborn T cells provides a better understanding of the immune response against RSV in early life and adulthood. RSV induces expression of Siglec‐1 on newborn and adult monocytes. Siglec‐1 inhibits RSV‐induced IFN‐γ release by adult T cells whereas the production of IFN‐γ by newborns is not affected by Siglec‐1. The expression of CD43, the natural ligand for Siglec‐1, is lower on newborn CD4+ T cells compared to adults.
Source: European Journal of Immunology - Category: Allergy & Immunology Authors: Tags: Research Article Source Type: research