Colorectal Carcinomas With Isolated Loss of PMS2 Staining by Immunohistochemistry.

CONCLUSIONS: - Unusual clinicopathologic features observed in colorectal carcinomas with isolated PMS2 loss are likely related to the high proportion of cases caused by germline mutations. Isolated PMS2-loss tumors may demonstrate more aggressive behavior than other tumors with microsatellite instability, but larger studies are needed to investigate that possibility further.
PMID: 29336605 [PubMed - as supplied by publisher]

Source: Archives of Pathology and Laboratory Medicine - January 16, 2018 Category: Laboratory Medicine Authors: Alpert L, Pai RK, Srivastava A, McKinnon W, Wilcox R, Yantiss RK, Arcega R, Wang HL, Robert ME, Liu X, Pai RK, Zhao L, Westerhoff M, Hampel H, Kupfer S, Setia N, Xiao SY, Hart J, Frankel WL Tags: Arch Pathol Lab Med Source Type: research