Clinical trials in menopause
Conclusions:The available literature suggests that HT is a viable option for the primary prevention of cardiovascular disease in postmenopausal women. Newer trials will likely verify this assessment. If this is enough to change clinical practice, however, remains to be seen given the general fear of HT by many with prescriptive authority, and also the women in our care. Objective: Clinical trials in menopause have undergone much scrutiny over the years. This has led to significant shifts in the treatment of symptomatic menopause and a substantial impact on women. We aim to delineate the key studies contributing to this controversy and highlight new directions specifically related to menopausal hormone therapy (HT) and vascular disease risk. Methods: We performed a search of sentinel studies delineating the risks and benefits of HT in otherwise healthy postmenopausal women. Using PubMed we input the following search terms: hormone replacement therapy, cardiovascular disease, coronary artery disease, coronary atherosclerosis, myocardial infarction, angina, coronary heart calcification, carotid intimal thickness, lipids, and/or lipoproteins. We included studies of menopausal women (surgical or natural) using combined estrogen/progestogen therapy or estrogen-only therapy that looked at cardiovascular disease risk factors or outcomes. Studies were evaluated for inclusion by the authors; however, this is not intended to be a systematic or an exhaustive analysis. Results: ...
Travel writer Ileana von Hirsch discovered that the experience of having cancer can have its comedic moments - and finding them makes all the difference.
(Reuters Health) - People who are married may be less likely to develop cardiovascular disease or die from a heart attack or stroke than individuals who aren't, a research review suggests.
It is critical for survival to assign positive or negative valence to salient stimuli in a correct manner. Accordingly, harmful stimuli and internal states characterized by perturbed homeostasis are accompanied by discomfort, unease, and aversion. Aversive signaling causes extensive suffering during chronic diseases, including inflammatory conditions, cancer, and depression. Here, we investigated the role of melanocortin 4 receptors (MC4Rs) in aversive processing using genetically modified mice and a behavioral test in which mice avoid an environment that they have learned to associate with aversive stimuli. In normal mice...
Receptor tyrosine kinases (RTKs) are important drivers of cancers. In addition to genomic alterations, aberrant activation of WT RTKs plays an important role in driving cancer progression. However, the mechanisms underlying how RTKs drive prostate cancer remain incompletely characterized. Here we show that non-proteolytic ubiquitination of RTK regulates its kinase activity and contributes to RTK-mediated prostate cancer metastasis. TRAF4, an E3 ubiquitin ligase, is highly expressed in metastatic prostate cancer. We demonstrated here that it is a key player in regulating RTK-mediated prostate cancer metastasis. We further i...
New J. Chem., 2018, Advance Article DOI: 10.1039/C8NJ01713A, PaperTania Lozano-Cruz, Rafael Gomez, F. Javier de la Mata, Paula Ortega A water soluble "bow-tie" cationic carbosilane dendrimer with curcumin in the core displays antioxidant and antitumoral activities against breast cancer cells. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Abstract Transfeminine individuals are treated with estradiol and anti-androgen agents to transition to a more feminine appearance. The physical changes that occur with estradiol therapy include breast development, body fat redistribution, and decreased muscle mass. Transfeminine treatment regimens require monitoring and dose adjustments to achieve appropriate physiologic targets to enhance feminization and decrease risk of adverse outcomes. Adverse effects associated with estradiol use include thromboembolic disease, macroprolactinoma, breast cancer, coronary artery disease, cerebrovascular disease, cholelithiasi...
Dewayne Joihnson, 46, of California, is the first person to go to trial claiming that weed killer Roundup is responsible for his cancer diagnosis while maker Monsanto denies these claims.
Recent-onset type 2 diabetes has been linked to pancreatic cancer in African Americans and Hispanics older than 50, according to a study.
DIABETES type 2 symptoms are not always apparent, but it ’s important to recognise all the signs or do what you can to prevent the condition as it can lead to other health problems such as heart disease and stroke. One of the ways to reduce your risk of diabetes is by eating a healthy, balanced diet. Certain drinks can make blood sugar spike, but the fo llowing five can help keep it level.
Buried in a new N.I.H. report are disturbing examples of coordination between scientists and the alcohol industry on a study that could have changed America ’ s drinking habits.
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