Clinical trials in menopause

Conclusions:The available literature suggests that HT is a viable option for the primary prevention of cardiovascular disease in postmenopausal women. Newer trials will likely verify this assessment. If this is enough to change clinical practice, however, remains to be seen given the general fear of HT by many with prescriptive authority, and also the women in our care. Objective: Clinical trials in menopause have undergone much scrutiny over the years. This has led to significant shifts in the treatment of symptomatic menopause and a substantial impact on women. We aim to delineate the key studies contributing to this controversy and highlight new directions specifically related to menopausal hormone therapy (HT) and vascular disease risk. Methods: We performed a search of sentinel studies delineating the risks and benefits of HT in otherwise healthy postmenopausal women. Using PubMed we input the following search terms: hormone replacement therapy, cardiovascular disease, coronary artery disease, coronary atherosclerosis, myocardial infarction, angina, coronary heart calcification, carotid intimal thickness, lipids, and/or lipoproteins. We included studies of menopausal women (surgical or natural) using combined estrogen/progestogen therapy or estrogen-only therapy that looked at cardiovascular disease risk factors or outcomes. Studies were evaluated for inclusion by the authors; however, this is not intended to be a systematic or an exhaustive analysis. Results: ...
Source: Menopause - Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research

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Publication date: 13 November 2018Source: Cell Reports, Volume 25, Issue 7Author(s): Anne Jørgensen, Joni Macdonald, John E. Nielsen, Karen R. Kilcoyne, Signe Perlman, Lene Lundvall, Lea Langhoff Thuesen, Kristine Juul Hare, Hanne Frederiksen, Anna-Maria Andersson, Niels E. Skakkebæk, Anders Juul, Richard M. Sharpe, Ewa Rajpert-De Meyts, Rod T. MitchellSummaryDisruption of human fetal testis development is widely accepted to underlie testicular germ cell cancer (TGCC) origin and additional disorders within testicular dysgenesis syndrome (TDS). However, the mechanisms for the development of testicular dysgenesi...
Source: Cell Reports - Category: Cytology Source Type: research
Publication date: 13 November 2018Source: Cell Reports, Volume 25, Issue 7Author(s): Daniel S.J. Miller, Robert D. Bloxham, Ming Jiang, Ilaria Gori, Rebecca E. Saunders, Debipriya Das, Probir Chakravarty, Michael Howell, Caroline S. HillSummarySignal transduction pathways stimulated by secreted growth factors are tightly regulated at multiple levels between the cell surface and the nucleus. The trafficking of cell surface receptors is emerging as a key step for regulating appropriate cellular responses, with perturbations in this process contributing to human diseases, including cancer. For receptors recognizing ligands of...
Source: Cell Reports - Category: Cytology Source Type: research
Radiation seems to specifically injure the brain region involved in learning and forming new memories.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
A California jury on Wednesday cleared Johnson&Johnson of liability in a case involving a woman who alleged that the company's talc-based products, including its baby powder, contain asbestos and caused her cancer, the company said.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Intricate pathway through which cancer cells likely spread to bone now opens the door to its pharmaceutical blockade and potentially mitigate against metastatic disease progression.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news
The objective of this study was to characterize Somali Bantu and Karen experiences with cancer and cancer screenings prior to and subsequent to resettlement in Buffalo, NY in order to inform engagement by health providers. METHODS: The study was grounded in a community-based participatory research approach, with data collection and analysis guided by the Health Belief Model and life course framework. Interviews were transcribed, independently coded by two researchers, and analyzed using an immersion-crystallization approach. We conducted 15 semi-structured interviews and six interview-focus group hybrids with Somali Ba...
Source: Journal of the National Medical Association - Category: General Medicine Tags: J Natl Med Assoc Source Type: research
This study focused on the possible role of SEC24 proteins in ATB0,+ trafficking. Rat ATB0,+ was expressed in HEK293 cells, its localization and trafficking were examined by Western blot, deglycosylation, immunofluorescence (co-localization with ER and trans-Golgi markers) and biotinylation. The expression of ATB0,+ at the plasma membrane was decreased by dominant negative mutants of SAR1, a GTPase, whose activity triggers the formation of the COPII complex. ATB0,+ co-precipitated with SEC24C (but not with the remaining isoforms A, B and D). This interaction was confirmed by immunocytochemistry and the proximity ligation as...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
This study is the first report on applicability of JgCSMV for Dox delivery with superior benefits over generally marketed formulations of doxorubicin.Graphical abstract
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
Publication date: Available online 13 November 2018Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Xiu-Mei Wang, Shi-Chao Fan, Yao Chen, Xiao-Feng Ma, Rong-Qiao HeAbstractBackgroundEarthworms are widely used in basic and applied research in medicine, food, environment and agriculture, in which for instance earthworm protease has its own biochemical features.Scope of reviewThis review summarizes earthworm protease biochemical features in anti-thrombosis and anti-fibrosis, and provides new perspectives for earthworm to be used in biochemical and pharmaceutical studies.Major conclusionsEarthworm prote...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
Publication date: March 2019Source: Microchemical Journal, Volume 145Author(s): Mehrab Fallahi-Samberan, Mehdi Salami-Kalajahi, Elham Dehghani, Farhang AbbasiAbstractDistillation precipitation polymerization (DPP) of acrylic acid were studied in the presence of two different crosslinkers including N,N′‑methylenebis(acrylamide) (MBA) and ethylene glycol dimethacrylate (EGDAMA). After morphological study of the resultant particles, the best morphological sample was selected as seed for seeded emulsion polymerization (SEP). Composite particles were fabricated by SEP of 2‑(dimethylamino)ethyl methacrylate (DMAEMA) an...
Source: Microchemical Journal - Category: Chemistry Source Type: research
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