Clinical trials in menopause

Conclusions:The available literature suggests that HT is a viable option for the primary prevention of cardiovascular disease in postmenopausal women. Newer trials will likely verify this assessment. If this is enough to change clinical practice, however, remains to be seen given the general fear of HT by many with prescriptive authority, and also the women in our care. Objective: Clinical trials in menopause have undergone much scrutiny over the years. This has led to significant shifts in the treatment of symptomatic menopause and a substantial impact on women. We aim to delineate the key studies contributing to this controversy and highlight new directions specifically related to menopausal hormone therapy (HT) and vascular disease risk. Methods: We performed a search of sentinel studies delineating the risks and benefits of HT in otherwise healthy postmenopausal women. Using PubMed we input the following search terms: hormone replacement therapy, cardiovascular disease, coronary artery disease, coronary atherosclerosis, myocardial infarction, angina, coronary heart calcification, carotid intimal thickness, lipids, and/or lipoproteins. We included studies of menopausal women (surgical or natural) using combined estrogen/progestogen therapy or estrogen-only therapy that looked at cardiovascular disease risk factors or outcomes. Studies were evaluated for inclusion by the authors; however, this is not intended to be a systematic or an exhaustive analysis. Results: ...
Source: Menopause - Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research

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ConclusionsOur results demonstrated that ddPCR could be used in detecting BRAF V600E mutation from FNA fluid samples with higher sensitivity and accuracy than ARMS.
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
CANCER symptoms cover a wide range of problems, some which may seem obvious while others are less so. Even simple things like a persistent cough, or frequent heartburn or indigestion could be a sign of some cancers, so it ’s important to monitor any changes to your body, no matter how small. If you suffer from heartburn or indigestion, here’s when to see a GP.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
AbstractBladder cancer is currently considered the most common malignancy of the urinary tract. Thulium laser en bloc resection of bladder tumor (TmLRBT) and plasmakinetic transurethral resection of bladder tumor (PK-TURBT) are two alternative common procedures used in our department to manage patients with primary non-muscle invasive bladder cancer (NMIBC) over the past decade. In this work, the safety and efficacy of TmLRBT were retrospectively compared to those of PK-TURBT in patients with primary NMIBC. From January 2013 to December 2015, 256 patients diagnosed with primary NMIBC were selected for this retrospective st...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
New J. Chem., 2019, Accepted Manuscript DOI: 10.1039/C8NJ06343E, PaperLin Ma, Wenjuan Gao, Xue Han, Fengli Qu, Lian Xia, Rong-Mei Kong Hyaluronidase (HAase) has been reported as a diagnostic and prognostic urinary biomarker for bladder cancer. Simple and sensitive methods capable of quantitative detection of HAase are desired for tumor diagnosis... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Haiming Liu, Nan Wu, Zhe Zhang, XiaoDan Zhong, Hao Zhang, Hao Guo, Yongzhan Nie, Yuanning Liu
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Patients receiving new kidneys and livers must take damaging anti-rejection drugs for the rest of their lives. Now researchers hope to train the immune system instead of just tamping it down.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Transplants Kidneys Organ Donation Liver Immune System Drugs (Pharmaceuticals) Dana-Farber Cancer Institute Massachusetts General Hospital University of Pittsburgh Medical Center Pittsburgh (Pa) Source Type: news
Review of patients admitted to the Veterans Affairs Healthcare System between October 1, 2002, and September 30, 2014.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Tags: Lower extremity arterial thromboembolisms occurring less frequently, but we are not doing much better in terms of outcomes Source Type: research
We report the case of a 60-year-old female with a history of chronic low back and legs pain secondary to L4 and L5 laminectomies posterior arthrodesis and fusion.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
This study aimed at exploring the effects of tDCS on negative emotion regulation as it pertains to ADHD related symptoms, which could potentially provide support for the use of the tDCS as an alternative treatment for ADHD.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
Vagal nerve stimulation is gaining recognition as an important therapeutic approach especially for non-communicable diseases such as cardiovascular disease (CVD), Depression, Fibromyalgia, Arthritis, Type 2 Diabetes, Alzheimer, and certain types of cancer. In turn, decreased vagal tone its implicated in the prognosis of a wide range of diseases. Afferent vagal stimulation seems to have the key to reset certain pathophysiological states of the body leading to health improvement by reshaping neural networks.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - Category: Neurology Authors: Source Type: research
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