Beta blockers and the inertia of evidence-based medicine

One of the key limitations of evidence-based medicine is that most evidence becomes outdated. Secular changes in the epidemiology, diagnosis, and treatment of disease invariably erode the continued relevance of even the most well conducted trials. As newer therapies are gradually stacked on the backs of older ones, the latter's effect sizes should tend to diminish or even disappear. Truly evidence-based medicine therefore requires a continuous reassessment of past successes, ideally through new randomized clinical trials in contemporary cohorts [1].
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Source Type: research