From Bad to Worse: Anemia on Admission and Hospital-Acquired Anemia

Background Anemia at hospitalization is often treated as an accompaniment to an underlying illness, without active investigation, despite its association with morbidity. Development of hospital-acquired anemia (HAA) has also been associated with increased risk for poor outcomes. Together, they may further heighten morbidity risk from bad to worse. Objectives The aims of this study were to (1) examine mortality, length of stay, and total charges in patients with present-on-admission (POA) anemia and (2) determine whether these are exacerbated by development of HAA. Design/Setting/Patients In this cohort investigation, from January 1, 2009, to August 31, 2011, a total of 44,483 patients with POA anemia were admitted to a single health system compared with a reference group of 48,640 without POA anemia or HAA. Measurements Data sources included the University HealthSystem Consortium database and electronic medical records. Risk-adjustment methods included logistic and linear regression models for mortality, length of stay, and total charges. Present-on-admission anemia was defined by administrative coding. Hospital-acquired anemia was determined by changes in hemoglobin values from the electronic medical record. Results Approximately one-half of the patients experienced worsening of anemia with development of HAA. Risk for death and resource use increased with increasing severity of HAA. Those who developed severe HAA had 2-fold greater odds for death; that is, mil...
Source: Journal of Patient Safety - Category: Health Management Tags: Original Articles Source Type: research

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Condition:   Aplastic Anemia Idiopathic Intervention:   Drug: Haploidentical HSCT using TBI free regimen, ''ATG'' with ''Post transplant cyclophosphamide'' Sponsor:   Armed Forces Bone Marrow Transplant Center, Rawalpindi, Pakistan Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractImmunosuppressive therapy (IST), consisting of anti thymocyte globulin and cyclosporine, is the standard of care for elderly patients and in younger patients without matched donor for stem cell transplant. In this retrospective study of 60 patients, most had non severe AA (51.6%) followed by very severe AA (26.7%) and severe AA (21.7%). The response rate at 6 months was 68.3% (complete response-3.3% and partial response-65%). Of the 45 who completed 12 months follow up, RR was 54.7% (CR-7.5%, PR-47.2 %). Eight patients died during the study period. Also, Indian data on IST is briefly reviewed.
Source: Indian Journal of Hematology and Blood Transfusion - Category: Hematology Source Type: research
This study aimed to evaluate hematology, biochemical constituents, acid-base balance, and blood gases in poor-performing anemic working horses. Thirty Egyptian Balady horses divided into two groups (15 healthy horses as a control group and 15 poor-performing anemic workin g horses). Blood samples were taken from each animal and divided into three portions, the first portion collected on EDTA tubes for hematology examination, the second portion collected on Heparin and sent immediately for blood gases and acid-base estimation, and the last portion collected on plain t ubes for serum separation. Giemsa-stained blood films we...
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research
CONCLUSION: The presence of CVID does not mean that it is necessary to give up on corticosteroids as a first-line treatment and rituximab as a second-line treatment for AIHA and ITP, but it should be in addition to immunoglobulin replacement. A splenectomy should be reserved as a third-line treatment. PMID: 31101329 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
ConclusionIn conclusion, portable blood (gas) analysis proved feasible in an HEMS operation but with relevant limitations. Future studies will have to show how these limitations can be overcome and how the implementation of portable blood (gas) analyzers may support improved patient outcome.
Source: Air Medical Journal - Category: Emergency Medicine Source Type: research
ConclusionsAs disparities in maternal and infant outcomes were present, nutritional intervention(s) need to be targeted towards prevention of adverse pregnancy outcomes, prioritization of higher-risk groups and adaptation of the program to a multi-ethnic low-income population.
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research
Debulking surgery, followed by taxane/platinum-based chemotherapy has traditionally been the first-line treatment for advanced ovarian cancer. However, most patients will experience recurrence afterwards, and receive subsequent lines of therapy. It has been proposed that extending the treatment-free interval of platinum can improve the response to a subsequent platinum-based chemotherapy, and reduce associated toxicities in women with recurrent, platinum-sensitive ovarian cancer. The aim was to determine the impact, in clinical practice, of trabectedin with pegylated liposomal doxorubicin (trabectedin/PLD) on the subsequen...
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: CLINICAL REPORT Source Type: research
Hemoglobin measurement is important for transfusion decision-making. Pulse CO-Oximetry provides real-time continuous hemoglobin (SpHb) monitoring. The triage role of SpHb trends based on hemoglobin measurement...
Source: BMC Anesthesiology - Category: Anesthesiology Authors: Tags: Research article Source Type: research
In conclusion, pacritinib, an inhibitor ofFLT3-ITD and resistant-conferring TKD mutations, was well tolerated and demonstrated preliminary anti-leukemic activity in combination with chemotherapy in patients withFLT3 mutations.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: This study suggests that parasite load together with malarial anemia, rather than alveolar leakage, might contribute to shortened survival in PbNK65-infected Vwf-/- mice. VWF deficiency is associated with early reticulocytosis following PbNK65 infection, which potentially explains the increase in parasite load. This article is protected by copyright. All rights reserved. PMID: 31099973 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: J Thromb Haemost Source Type: research
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