From Bad to Worse: Anemia on Admission and Hospital-Acquired Anemia

Background Anemia at hospitalization is often treated as an accompaniment to an underlying illness, without active investigation, despite its association with morbidity. Development of hospital-acquired anemia (HAA) has also been associated with increased risk for poor outcomes. Together, they may further heighten morbidity risk from bad to worse. Objectives The aims of this study were to (1) examine mortality, length of stay, and total charges in patients with present-on-admission (POA) anemia and (2) determine whether these are exacerbated by development of HAA. Design/Setting/Patients In this cohort investigation, from January 1, 2009, to August 31, 2011, a total of 44,483 patients with POA anemia were admitted to a single health system compared with a reference group of 48,640 without POA anemia or HAA. Measurements Data sources included the University HealthSystem Consortium database and electronic medical records. Risk-adjustment methods included logistic and linear regression models for mortality, length of stay, and total charges. Present-on-admission anemia was defined by administrative coding. Hospital-acquired anemia was determined by changes in hemoglobin values from the electronic medical record. Results Approximately one-half of the patients experienced worsening of anemia with development of HAA. Risk for death and resource use increased with increasing severity of HAA. Those who developed severe HAA had 2-fold greater odds for death; that is, mil...
Source: Journal of Patient Safety - Category: Health Management Tags: Original Articles Source Type: research

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Publication date: Available online 21 February 2019Source: Anaesthesia &Intensive Care MedicineAuthor(s): Alwyn KotzéAbstractPreoperative anaemia is common. Its prevalence varies according to the population studied and the definition of what constitutes anaemia. Where the widely accepted definition of the World Health Organization is used (haemoglobin concentration
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
CD5+ B lymphocytes secrete IL-10 rather than TGF-β1 which control the immune response in autoimmune haemolytic anaemia/Evans syndrome. Autoimmunity. 2019 Feb 20;:1-9 Authors: Zhao M, Duan N, Wang Y, Zhu H, Liu H, Wang H, Xing L, Shao Z Abstract OBJECTIVE: To investigate the quantity and secretion function of cytokines-secreted CD5+ B lymphocytes in Autoimmune Haemolytic Anaemia (AIHA)/Evans syndrome (ES) patients. METHODS: Twenty-five untreated AIHA/ES patients, 28 remission AIHA/ES patients and 25 healthy controls (HCs) were enrolled in this study. The quantity of CD5+B lymphocytes which prod...
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
Treatment with Noripurum EV® is effective and safe in pediatric patients with inflammatory bowel disease and iron deficiency anemia. Scand J Gastroenterol. 2019 Feb 20;:1-7 Authors: Venturieri MO, Komati JTS, Lopes LHC, Sdepanian VL Abstract OBJECTIVES: To evaluate the therapeutic response and adverse effects of Noripurum EV® in children and adolescents with inflammatory bowel disease (IBD) and iron deficiency anemia. MATERIALS AND METHODS: Cohort study involving patients with Crohn's disease (CD) and ulcerative colitis (UC) who received treatment for iron deficiency anemia with Noripurum E...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Publication date: Available online 21 February 2019Source: The American Journal of SurgeryAuthor(s): Tyler J. Loftus, Elizabeth S. Miller, Jessica K. Millar, Kolenkode B. Kannan, Ines G. Alamo, Philip A. Efron, Alicia M. MohrAbstractBac’kgroundAttenuating post-injury neuroendocrine stress abrogates persistent injury-associated anemia. Our objective was to examine the mechanisms by which propranolol and clonidine modulate this process. We hypothesized that propranolol and clonidine would decrease bone marrow expression of high-mobility group box-1 (HMGB1) and increase expression of stem cell factor (SCF) and B-cell ly...
Source: The American Journal of Surgery - Category: Surgery Source Type: research
Allogeneic blood transfusion for anemia correction before surgery has been independently associated with postoperative morbidity and mortality in multiple surgical fields. Blood transfusion has been identified as one of the most overused treatments in US hospitals and is associated with a significant health care expenditure. Our objective is to investigate the impact of preoperative blood transfusion on postoperative complications following laparoscopic hysterectomy done for benign indications.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Oral Poster Source Type: research
SummaryPurpose To elucidate the radiosensitizing effect and underlying mechanism of a new kind of DNA methyltransferase (DNMT) inhibitor with biological availability.Methods A novel non-nucleoside compound, designated as MA-17, was recently derived from a phthalimido alkanamide structure. DNMT expressions were confirmed in cultured human lung cancer (A549) and normal astrocyte (NHA) cells, radiosensitivity was measured using clonogenic assay, and assays of cell cycle alteration, apoptosis, DNA damage repair, and differential gene expression were undertaken.Results MA-17 significantly radiosensitized A549 cells with a mean ...
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
Genes, Vol. 10, Pages 170: Holding All the Cards—How Fanconi Anemia Proteins Deal with Replication Stress and Preserve Genomic Stability Genes doi: 10.3390/genes10020170 Authors: Datta Brosh Jr. Fanconi anemia (FA) is a hereditary chromosomal instability disorder often displaying congenital abnormalities and characterized by a predisposition to progressive bone marrow failure (BMF) and cancer. Over the last 25 years since the discovery of the first linkage of genetic mutations to FA, its molecular genetic landscape has expanded tremendously as it became apparent that FA is a disease characterized by a def...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Review Source Type: research
ConclusionWe have shown a prevalence of 11.8% for AIC among our CLL patients. AIC was associated with unsatisfactory normalization of the hematological parameters even with therapy and lower number of patients with CLL downstaging in comparison with patients without AIC. These results suggest that AIC is a fingerprint of a biologically more aggressive disease even if no significant impact on overall survival was found.
Source: Hematology Oncology and Stem Cell Therapy - Category: Cancer & Oncology Source Type: research
In conclusion, porcine hemoplasmas have a high rate of prevalence in sows from commercial farms in the southern region of Brazil. This study demonstrated the first molecular detection and characterization of partial 16S rRNA gene of M. parvum in Brazil.
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
We report a case of a 16-year-old female who presented with bleeding diathesis. Peripheral blood film examination was consistent with microangiopathic hemolytic anemia with 7% fragmented red blood cells. The ADAMTS13 level was 40 ng/ml (reference range: 630–850 ng/ml). She responded to plasma exchange therapy and methylprednisolone and was discharged in a stable condition.
Source: International Journal of Pediatrics and Adolescent Medicine - Category: Pediatrics Source Type: research
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