Histopathological and molecular classification of colorectal cancer and corresponding peritoneal metastases

ConclusionSignificant enrichment for CMS4 was observed in colorectal peritoneal carcinomatosis. Surgical relevanceCytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS‐HIPEC) improves survival of selected patients with colorectal peritoneal carcinomatosis, but recurrence is common. Histopathological and molecular analysis of colorectal peritoneal carcinomatosis could provide clues for development of novel therapies.In this study, colorectal peritoneal carcinomatosis was found to be enriched for tumours with high stromal content and CMS4‐positive status.To further improve prognosis for patients with colorectal peritoneal carcinomatosis, therapies that target tumour–stroma interaction could be added to CRS‐HIPEC.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fbjs.10788

Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: I. Ubink, W. J. van Eden, P. Snaebjornsson, N. F. M. Kok, J. van Kuik, W. M. U. van Grevenstein, M. M. Lacl é, J. Sanders, R. J. A. Fijneman, S. G. Elias, I. H. M. Borel Rinkes, A. G. J. Aalbers, O. Kranenburg Tags: Original article Source Type: research