Genotype and risk of tumour rupture in gastrointestinal stromal tumour

ConclusionGastric GISTs with KIT exon 11 deletions involving codons 557 and 558 are at increased risk of tumour rupture. This high‐risk feature can be identified in the diagnostic evaluation and should be included in the assessment when neoadjuvant imatinib treatment is considered.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fbjs.10743

Source: British Journal of Surgery - January 17, 2018 Category: Surgery Authors: K. Boye, J. ‐M. Berner, I. Hompland, Ø. S. Bruland, S. Stoldt, K. Sundby Hall, B. Bjerkehagen, T. Hølmebakk Tags: Original article Source Type: research